1-(3-Chlorophenyl)pyrrolidin-2-one

Base Information

• Chemical Name: 1-(3-Chlorophenyl)pyrrolidin-2-one
• CAS No.: 24051-35-2
• Molecular Formula: C10H10ClNO
• Molecular Weight: 195.648
• Hs Code.: 2933790090
• Mol file: 24051-35-2.mol

Synonyms:1-(3-chlorophenyl)-2-oxotetrahydropyrrole;1-(3-chlorophenyl)-2-pyrrolidone;1-(3-chloro-phenyl)-pyrrolidin-2-one;N-(3-chlorophenyl)-2-pyrrolidinone;1-(3-Chlor-phenyl)-pyrrolidin-2-on;1-(3'-Cl-phenyl)-2-pyrrolidinone;

Chemical Property of 1-(3-Chlorophenyl)pyrrolidin-2-one

Chemical Property:

• Melting Point: 66 °C
• Boiling Point: 143 °C(Press: 0.7 Torr)
• PKA: -0.61±0.20(Predicted)
• PSA: 20.31000
• Density: 1.283±0.06 g/cm3(Predicted)
• LogP: 2.53180
• Storage Temp.: 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

1-(3-Chlorophenyl)pyrrolidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-Chlorophenyl)pyrrolidin-2-one

There total 3 articles about 1-(3-Chlorophenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-pyrrolidinon (616-45-5) + 3-iodochlorobenzene (625-99-0) → 1-(3-chlorophenyl)-2-oxotetrahydropyrrole (24051-35-2)

Guidance literature:

With cobalt(II) oxalate dihydrate; caesium carbonate; N,N`-dimethylethylenediamine; In water; at 120 ℃; for 24h; Green chemistry;

DOI:10.1055/s-0034-1380724

Reference yield: 44.0%

2-pyrrolidinon (616-45-5) + 1,3-Dichlorobenzene (541-73-1) → 1-(3-chlorophenyl)-2-oxotetrahydropyrrole (24051-35-2)

Guidance literature:

With potassium acetate; CuO/SiO₂; for 7h; Heating;

DOI:10.1055/s-1985-31364

Reference yield:

4-butanolide (96-48-0) + 3-chloro-aniline (108-42-9) → 1-(3-chlorophenyl)-2-oxotetrahydropyrrole (24051-35-2)

Guidance literature:

at 300 ℃;

upstream raw materials:

4-butanolide

3-chloro-aniline

2-pyrrolidinon

1,3-Dichlorobenzene

Refernces

• 1、 Tan, Bryan Yong-Hao,Teo, Yong-Chua. "Mild and Efficient Cobalt-Catalyzed Cross-Coupling of Aliphatic Amides and Aryl Iodides in Water". supporting information. p. 1697 - 1701. Retrieved 2015/07/20.
• 2、 Renger, Bernd. "Direkte N-Arylierung von Amiden: Eine Verbesserung der Goldberg-Reaktion". . p. 856 - 860. Retrieved 2007/10/02.