Pyrido[1,2-a]indole

Base Information

• Chemical Name: Pyrido[1,2-a]indole
• CAS No.: 245-43-2
• Molecular Formula: C12H9N
• Molecular Weight: 167.21
• Mol file: 245-43-2.mol

Synonyms:Pyrido[1,2-a]indol;pyrido[1,2-a]indole;benzindolizine;

Chemical Property of Pyrido[1,2-a]indole

Chemical Property:

• Melting Point: 173.5-174.0 °C(Solv: ethanol (64-17-5))
• Boiling Point: 110-174 °C(Press: 3 Torr)
• PSA: 4.41000
• Density: 1.10±0.1 g/cm3(Predicted)
• LogP: 3.09250

Purity/Quality:

Pyrido[1,2-a]indole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[1,2-a]indole

There total 12 articles about Pyrido[1,2-a]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-benzylpyridine-N-oxide (20531-86-6) → benzo<2,3>indolizine (245-43-2)

Guidance literature:

at 800 ℃; under 0.1 Torr;

DOI:10.1246/cl.1981.1737

Reference yield: 63.0%

2-benzylpyridine-N-oxide (20531-86-6) → 2-Benzylpyridine (101-82-6) + benzo<2,3>indolizine (245-43-2)

Guidance literature:

at 800 ℃; for 0.25h; under 0.05 - 0.2 Torr;

DOI:10.1021/jo00139a022

Reference yield: 52.0%

6,9-dihydropyrido[1,2-a]indole (1256929-14-2) → benzo<2,3>indolizine (245-43-2)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In ethyl acetate; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01827

upstream raw materials:

2-Benzylpyridine

benzene

2-benzylpyridine-N-oxide

6,9-dihydropyrido[1,2-a]indole

Downstream raw materials:

6,7,8,9-tetrahydropyrido[1,2-a]indole

5-benzoylbenzo<2,3>indolizine

1,2,3,4,10,10a-hexahydropyrido<1,2-a>indole

Refernces

• 1、 Soldatenkov, A. T.,Bagdadi, M. V.,Fomichev, A. A.,Prostakov, N. S.. "A NEW METHOD FOR THE PRODUCTION OF BENZINDOLIZINES". . p. 783. Retrieved 2007/10/02.
• 2、 Ohsawa, Akio,Kawaguchi, Takayuki,Igeta, Hiroshi. "FLASH VACUUM PYROLYSIS OF 2-BENZYLPYRIDINE N-OXIDES. SYNTHESIS OF METHYLPYRIDOINDOLES". . p. 1737 - 1738. Retrieved 2007/10/02.