AKOS B028939

Base Information

• Chemical Name: AKOS B028939
• CAS No.: 24581-99-5
• Molecular Formula: C10H9BrO4
• Molecular Weight: 273.083
• Hs Code.: 2918990090
• Mol file: 24581-99-5.mol

Synonyms:(4-bromo-2-formylphenoxy)acetic acid methyl ester;methyl (4-bromo-2-formylphenoxy)acetate(SALTDATA: FREE);acetic acid,(4-bromo-2-formylphenoxy)-,methyl ester;

Chemical Property of AKOS B028939

Chemical Property:

• Vapor Pressure: 2.6E-05mmHg at 25°C
• Boiling Point: 358.1oC at 760 mmHg
• Flash Point: 170.4oC
• PSA: 52.60000
• Density: 1.536g/cm3
• LogP: 1.81340

Purity/Quality:

98%min ^*data from raw suppliers

methyl(4-bromo-2-formylphenoxy)acetate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS B028939

There total 2 articles about AKOS B028939 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl bromoacetate (105-36-2) + 5-bromosalicyclaldehyde (1761-61-1) → methyl (4-bromo-2-formylphenoxy)acetate (24581-99-5)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; for 15h; Ambient temperature;

DOI:10.1021/jm970020k

Reference yield:

bromoacetic acid methyl ester (96-32-2) + 5-bromosalicyclaldehyde (1761-61-1) → methyl (4-bromo-2-formylphenoxy)acetate (24581-99-5)

Guidance literature:

Multistep reaction; (i) NaH, DMF, (ii) /BRN= 506256/;

DOI:10.1021/jm00303a018

Reference yield: 49.0%

methyl (4-bromo-2-formylphenoxy)acetate (24581-99-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-[5-bromo-2-(carbomethoxymethyloxy)]phenyl-3-hydroxy-2-methylenepropanoate (1370710-79-4)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; triethanolamine; at 20 ℃; for 6h; Neat (no solvent);

DOI:10.5012/bkcs.2012.33.1.233

upstream raw materials:

bromoacetic acid methyl ester

5-bromosalicyclaldehyde

ethyl bromoacetate

Downstream raw materials:

2-(4-bromo-2-formylphenoxy)acetic acid

5-bromo-2-benzofurancarboxylic acid methyl ester

5-cyanobenzo[b]furan-2-carboxylic acid

methyl 5-cyanobenzofuran-2-carboxylate

Refernces