Technology Process of 1-Pyrrolidinecarboxylic acid,
3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[[(methylsulfonyl)oxy]methyl]-,
phenylmethyl ester, (3S,4S)-
There total 7 articles about 1-Pyrrolidinecarboxylic acid,
3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[[(methylsulfonyl)oxy]methyl]-,
phenylmethyl ester, (3S,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at -10 - 20 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetone / 20 °C
1.2: 48 h / 20 °C
2.1: sulfuric acid / ethanol; water / 16 h / 20 °C
2.2: 4 h / 10 - 20 °C / pH 10
3.1: triethylamine / dichloromethane / 1.5 h / -10 - 20 °C
With
sulfuric acid; triethylamine;
In
ethanol; dichloromethane; water; acetone;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydroxide / water; toluene / 4 h / 10 - 20 °C
2.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / toluene
2.2: 20 - 30 °C
3.1: formic acid / 15 h / 20 °C
4.1: hydroxylamine hydrochloride; sodium acetate / water; acetonitrile / 20 h / 20 °C
5.1: xylene / 10 h / Heating / reflux
5.2: 3 h / 10 - 20 °C
6.1: acetone / 20 °C
6.2: 48 h / 20 °C
7.1: sulfuric acid / ethanol; water / 16 h / 20 °C
7.2: 4 h / 10 - 20 °C / pH 10
8.1: triethylamine / dichloromethane / 1.5 h / -10 - 20 °C
With
potassium hydroxide; sodium hydroxide; formic acid; sulfuric acid; hydroxylamine hydrochloride; N-benzyl-N,N,N-triethylammonium chloride; sodium acetate; triethylamine;
In
ethanol; dichloromethane; water; acetone; toluene; acetonitrile; xylene;