2,5-Diiodophenol

Base Information

• Chemical Name: 2,5-Diiodophenol
• CAS No.: 24885-47-0
• Molecular Formula: C6H4I2O
• Molecular Weight: 345.906
• Hs Code.: 2908199090
• DSSTox Substance ID: DTXSID501316572
• Nikkaji Number: J801.817K
• Wikidata: Q209232
• Mol file: 24885-47-0.mol

Synonyms:2,5-DIIODOPHENOL;24885-47-0;2,5-diiodo-phenol;SCHEMBL3920223;BPJGGVMYBHUGEC-UHFFFAOYSA-N;DTXSID501316572;MB07529;Q209232

Chemical Property of 2,5-Diiodophenol

Chemical Property:

• Boiling Point: 283.3±25.0 °C(Predicted)
• PKA: 7.66±0.10(Predicted)
• PSA: 20.23000
• Density: 2.620±0.06 g/cm3(Predicted)
• LogP: 2.60140
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 345.83516
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

2,5-DIIODOPHENOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1I)O)I

Technology Process of 2,5-Diiodophenol

There total 2 articles about 2,5-Diiodophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-Iodophenol (626-02-8) → 2,5-diiodophenol (24885-47-0)

Guidance literature:

3-Iodophenol; With ammonium iodide; In methanol; at 0 ℃; for 0.0333333h;

With potassium phosphate; In methanol; for 0.0833333h;

DOI:10.1021/acs.joc.9b00161

Reference yield:

2,4-diiodoaniline (64085-53-6) → 2,5-diiodophenol (24885-47-0)

Guidance literature:

Diazotization;

Reference yield: 99.0%

2,5-diiodophenol (24885-47-0) + methyl iodide (74-88-4) → 1,4-diiodo-2-methoxybenzene (906557-98-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

2,4-diiodoaniline

3-Iodophenol

Downstream raw materials:

2-(2,5-diiodo-phenoxy)-butyric acid

(2,5-diiodo-phenoxy)-acetic acid

<2.5-Diiod-phenoxy>-essigsaeure-ethylester

acetic acid-(2,5-diiodo-phenyl ester)

Refernces

• 1、 Satkar, Yuvraj,Yera-Ledesma, Luisa F.,Mali, Narendra,Patil, Dipak,Segura-Quezada, Luis A.,Ramírez-Morales, Perla I.,Solorio-Alvarado, César R.,Navarro-Santos, Pedro. "Iodine(III)-Mediated, Controlled Di- or Monoiodination of Phenols". . p. 4149 - 4164. Retrieved 2019/04/30.
• 2、 -. "Diaminopyrimidines as P2X3 and P2X2/3 modulators". Page/Page column 36. . Retrieved 2008/06/13.