N-(4-(Aminomethyl)phenyl)acetamide hydrochloride

Base Information

• Chemical Name: N-(4-(Aminomethyl)phenyl)acetamide hydrochloride
• CAS No.: 25027-73-0
• Molecular Formula: C9H12N2O.ClH
• Molecular Weight: 200.668
• European Community (EC) Number: 858-384-8
• DSSTox Substance ID: DTXSID00589623
• Mol file: 25027-73-0.mol

Synonyms:25027-73-0;N-(4-(Aminomethyl)phenyl)acetamide hydrochloride;N-[4-(aminomethyl)phenyl]acetamide hydrochloride;N-[4-(aminomethyl)phenyl]acetamide;hydrochloride;MFCD06656043;N-(4-(Aminomethyl)phenyl)acetamide HCl;N-[4-(AMINOMETHYL)PHENYL]ACETAMIDE HCL;Acetamide, N-[4-(aminomethyl)phenyl]-, monohydrochloride;Mandelic acid, acetate;SCHEMBL8649176;DTXSID00589623;4-Acetamidobenzylamine hydrochloride;AKOS022186149;DS-7766;SB77804;SY111828;DB-198864;CS-0130398;EN300-26838;F19945;4-acetamidobenzylamine hydrochloride, AldrichCPR;N-[4-(Aminomethyl)phenyl]acetamide--hydrogen chloride (1/1)

Chemical Property of N-(4-(Aminomethyl)phenyl)acetamide hydrochloride

Chemical Property:

• Melting Point: 292-294 °C
• PSA: 58.61000
• LogP: 3.25550
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 200.0716407
• Heavy Atom Count: 13
• Complexity: 151

Purity/Quality:

98%Min ^*data from raw suppliers

N-(4-(Aminomethyl)phenyl)acetamidehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)CN.Cl

Technology Process of N-(4-(Aminomethyl)phenyl)acetamide hydrochloride

There total 6 articles about N-(4-(Aminomethyl)phenyl)acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(4-cyanophenyl)acetamide (35704-19-9) → (4-acetamidophenyl)methanammonium chloride (25027-73-0)

Guidance literature:

N-(4-cyanophenyl)acetamide; With hydrogen; at 130 ℃; for 6h; under 750.075 Torr;

chemoselective reaction; Acidic conditions;

DOI:10.1021/acscatal.0c04379

Reference yield: 85.0%

4-acetamidobenzyl azide → (4-acetamidophenyl)methanammonium chloride (25027-73-0)

Guidance literature:

4-acetamidobenzyl azide; With triphenylphosphine; at 110 ℃; for 20h; Green chemistry;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; Green chemistry;

DOI:10.1039/c8gc02136h

Reference yield: 84.0%

acetic anhydride (108-24-7) + 4-(aminomethyl)aniline dihydrochloride (10003-73-3,54799-03-0,140401-57-6) → (4-acetamidophenyl)methanammonium chloride (25027-73-0) + N-(4-aminobenzyl)acetamide hydrochloride (24095-59-8)

Guidance literature:

With sodium hydroxide; In water; pH 4.15;

DOI:10.1021/ja00034a040

upstream raw materials:

acetic anhydride

4-(aminomethyl)aniline dihydrochloride

tert-butyl N-[(4-acetylamino)benzyl]carbamate

N-(4-cyanophenyl)acetamide

Downstream raw materials:

N-(4-acetamidobenzyl)acetamide

Refernces

• 1、 Lenstra, Danny C.,Wolf, Joris J.,Mecinovi?, Jasmin. "Catalytic Staudinger Reduction at Room Temperature". . p. 6536 - 6545. Retrieved 2019/05/24.
• 2、 Adam, Rosa,Alberico, Elisabetta,Baumann, Wolfgang,Drexler, Hans-Joachim,Jackstell, Ralf,Junge, Henrik,Beller, Matthias. "NNP-Type Pincer Imidazolylphosphine Ruthenium Complexes: Efficient Base-Free Hydrogenation of Aromatic and Aliphatic Nitriles under Mild Conditions". . p. 4991 - 5002. Retrieved 2016/04/05.