3H-Imidazo[4,5-c]pyridine, 2-phenyl-

Base Information

• Chemical Name: 3H-Imidazo[4,5-c]pyridine, 2-phenyl-
• CAS No.: 75007-92-0
• Molecular Formula: C12H9N3
• Molecular Weight: 195.224
• Hs Code.: 2933990090
• Mol file: 75007-92-0.mol

Synonyms:2-phenyl-1h-imidazo[4,5-c]pyridine;2-Phenyl-1H-imidazo<2-phenylimidazo[4,5-c]pyridine;2-phenylimidazo-<4,5-c>-pyridine;2-Phenylimidazo

Chemical Property of 3H-Imidazo[4,5-c]pyridine, 2-phenyl-

Chemical Property:

• Vapor Pressure: 1.51E-07mmHg at 25°C
• Melting Point: 229-230℃
• Boiling Point: 428.5°Cat760mmHg
• PKA: 9.45±0.30(Predicted)
• Flash Point: 206.8°C
• PSA: 41.57000
• Density: 1.27g/cm³
• LogP: 2.62490

Purity/Quality:

99.00% ^*data from raw suppliers

2-phenyl-5H-imidazo[4,5-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-Imidazo[4,5-c]pyridine, 2-phenyl-

There total 27 articles about 3H-Imidazo[4,5-c]pyridine, 2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,4-diaminopyridine (54-96-6) + benzoic acid (65-85-0,8013-63-6) → 2-Phenyl-1H-imidazo<4,5-c>pyridine (75007-92-0)

Guidance literature:

With PPA; at 190 ℃; for 3h;

DOI:10.1016/j.bmcl.2006.07.081

Reference yield: 91.0%

3,4-diaminopyridine (54-96-6) + benzaldehyde (100-52-7) → 2-Phenyl-1H-imidazo<4,5-c>pyridine (75007-92-0)

Guidance literature:

With sulfur; at 165 - 175 ℃; for 4h;

DOI:10.1007/BF00476381

Reference yield: 90.0%

N-(3-aminopyridin-4-yl)benzamide (918550-20-6) → 2-Phenyl-1H-imidazo<4,5-c>pyridine (75007-92-0)

Guidance literature:

With hydrogenchloride; In butan-1-ol; for 1h; Heating;

DOI:10.1002/jhet.5570360505

upstream raw materials:

3,4-diaminopyridine

benzaldehyde

N-benzylpyridinium chloride

benzoic acid

Downstream raw materials:

3-benzyl-2-phenylimidazo[4,5-c]pyridine

C₂₆H₂₂N₈O₅S₂

Refernces

• 1、 Yutilov, Yu. M.,Shcherbina, L. I.. "UNUSUAL FORMATION OF AN IMIDAZOPYRIDINE DERIVATIVES". . p. 1251. Retrieved 1981.
• 2、 Arnold, Eric P.,Mondal, Prolay K.,Schmitt, Daniel C.. "Oxidative Cyclization Approach to Benzimidazole Libraries". . p. 1 - 5. Retrieved 2020/02/20.
• 3、 Marri, Mahender Reddy,Peraka, Swamy,Macharla, Arun Kumar,Mameda, Naresh,Kodumuri, Srujana,Nama, Narender. "Catalyst-free one-pot synthesis of benzimidazoles from 1,2-diaminoarenes and alcohols". supporting information. p. 6520 - 6525. Retrieved 2015/01/08.