2-(1,1-Difluoroethoxy)-1,1,1-trifluoroethane

Base Information

• Chemical Name: 2-(1,1-Difluoroethoxy)-1,1,1-trifluoroethane
• CAS No.: 25352-91-4
• Molecular Formula: C4H5F5O
• Molecular Weight: 164.07400
• Hs Code.: 2909199090
• European Community (EC) Number: 641-288-3
• DSSTox Substance ID: DTXSID80474265
• Wikidata: Q27459200
• Mol file: 25352-91-4.mol

Synonyms:25352-91-4;2-(1,1-DIFLUOROETHOXY)-1,1,1-TRIFLUOROETHANE;1,1-Difluoroethyl 2,2,2-trifluoroethyl ether;SCHEMBL6052677;DTXSID80474265;LUGFHDZVRRASHY-UHFFFAOYSA-N;AKOS006287136;1,1-Difluoroethyl2,2,2-trifluoroethylether;Q27459200

Chemical Property of 2-(1,1-Difluoroethoxy)-1,1,1-trifluoroethane

Chemical Property:

• Vapor Pressure: 437.609mmHg at 25°C
• Boiling Point: 40.28oC at 760 mmHg
• Flash Point: -17.109oC
• PSA: 9.23000
• Density: 1.279g/cm3
• LogP: 2.17800
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 164.02605559
• Heavy Atom Count: 10
• Complexity: 107

Purity/Quality:

97% ^*data from raw suppliers

1,1-Difluoroethyl 2,2,2-trifluoroethyl ether 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(OCC(F)(F)F)(F)F

Technology Process of 2-(1,1-Difluoroethoxy)-1,1,1-trifluoroethane

There total 3 articles about 2-(1,1-Difluoroethoxy)-1,1,1-trifluoroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-1,1-difluoroethane (359-07-9) + 2,2,2-trifluoroethanol (75-89-8) → 2-(2,2-difluoroethoxy)-1,1,1-trifluoroethane + (1,1-difluoro-ethyl)-(2,2,2-trifluoro-ethyl)-ether (25352-91-4) + C4H4F4O

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In water; at 80 ℃; for 16h; Overall yield = 66 %; Overall yield = 50 g; Autoclave;

Reference yield:

1-Chloro-1,1-difluoroethane (75-68-3) + 2,2,2-trifluoroethanol (75-89-8) → (1,1-difluoro-ethyl)-(2,2,2-trifluoro-ethyl)-ether (25352-91-4)

Guidance literature:

With sodium; at 200 ℃; under 26478.3 Torr;

DOI:10.1021/ja01166a013

Reference yield:

→ (1,1-difluoro-ethyl)-(2,2,2-trifluoro-ethyl)-ether (25352-91-4)

Guidance literature:

Trifluorethanol, KOH, Difluorethylen;

upstream raw materials:

1-Chloro-1,1-difluoroethane

2,2,2-trifluoroethanol

2-bromo-1,1-difluoroethane

Refernces

• 1、 -. "METHODS FOR PREPARATION OF FLUORINATED ETHERS". Page/Page column 16-17. . Retrieved 2015/04/22.