(2S,5R)-1-BENZYL-2,5-DIMETHYLPIPERAZINE

Base Information

• Chemical Name: (2S,5R)-1-BENZYL-2,5-DIMETHYLPIPERAZINE
• CAS No.: 260254-80-6
• Molecular Formula: C13H20N2
• Molecular Weight: 204.315
• Mol file: 260254-80-6.mol

Synonyms:1-benzyl-2R,5S-dimethyl-piperazine;N-benzyl-2S,5R-dimethylpiperazine;I13-0205;trans-2R,5S-dimethyl-4-benzyl-piperazine;1-Benzyl-trans-2,5-dimethyl-piperazin;

Chemical Property of (2S,5R)-1-BENZYL-2,5-DIMETHYLPIPERAZINE

Chemical Property:

• Boiling Point: 291.5±20.0 °C(Predicted)
• PKA: 9.35±0.60(Predicted)
• PSA: 15.27000
• Density: 0.964±0.06 g/cm3(Predicted)
• LogP: 2.13550

Purity/Quality:

NLT 98% ^*data from raw suppliers

(2S,5R)-1-Benzyl-2,5-dimethyl-piperazine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,5R)-1-BENZYL-2,5-DIMETHYLPIPERAZINE

There total 9 articles about (2S,5R)-1-BENZYL-2,5-DIMETHYLPIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (431062-00-9) → trans-2R,5S-dimethyl-4-benzyl-piperazine (260254-80-6,3138-88-3,324750-43-8,745031-35-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 1h; Product distribution / selectivity;

Reference yield: 81.0%

C13H20N2 (3138-88-3,324750-43-8,745031-35-0) → trans-2R,5S-dimethyl-4-benzyl-piperazine (260254-80-6,3138-88-3,324750-43-8,745031-35-0)

Guidance literature:

C₁₃H₂₀N₂; With L-Tartaric acid; In methanol; at 0 - 20 ℃; for 24.33h;

With sodium carbonate; In water; pH=9 - 10; Purification / work up;

Reference yield:

benzyl bromide (100-39-0) + 2,5-dimethyl-piperazine (2815-34-1,1119702-25-8) → trans-2R,5S-dimethyl-4-benzyl-piperazine (260254-80-6,3138-88-3,324750-43-8,745031-35-0) + (-)-(2R,5S)-1-benzyl-2,5-dimethylpiperazine (216532-43-3,3138-88-3,324750-43-8,745031-35-0)

Guidance literature:

In ethanol; at 20 ℃;

upstream raw materials:

(+/-)-trans-2,5-dimethyl-4-benzyl-piperazine

4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

Boc-(R)-Ala

N-benzyl-L-alanine methyl ester

Downstream raw materials:

4-(((2R,5S)-4-benzyl-2,5-dimethylpiperazin-1-yl)methyl)tetrahydro-2H-pyran-4-ol

(2S,5R)-1-benzyl-2,5-dimethyl-4-(3,3,3-trifluoropropyl)piperazine

(2S,5R)-1-benzyl-2,5-dimethyl-4-(tetrahydro-2H-pyran-4-ylmethyl)piperazine

(2S,5R)-1-benzyl-2,5-dimethyl-4-(tetrahydro-2H-pyran-4-yl)piperazine

Refernces

• 1、 -. "3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES AS INHIBITORS OF PROTEIN KINASE C". Page/Page column 20; 22. . Retrieved 2008/12/08.
• 2、 Mavunkel, Babu J.,Chakravarty, Sarvajit,Perumattam, John J.,Luedtke, Gregory R.,Liang, Xi,Lim, Don,Xu, Yong-Jin,Laney, Maureen,Liu, David Y.,Schreiner, George F.,Lewicki, John A.,Dugar, Sundeep. "Indole-based heterocyclic inhibitors of p38α MAP kinase: Designing a conformationally restricted analogue". . p. 3087 - 3090. Retrieved 2007/10/03.