ETHYL 4-ETHOXYBUTYRATE

Base Information

• Chemical Name: ETHYL 4-ETHOXYBUTYRATE
• CAS No.: 26448-91-9
• Molecular Formula: C8H16O3
• Molecular Weight: 160.213
• Hs Code.: 2918990090
• Mol file: 26448-91-9.mol

Synonyms:4-ethoxybutyric acid ethyl ester;4-Aethoxy-buttersaeure-aethylester;I04-9500;Ethyl 4-ethoxybutyrate;Ethyl-4-ethoxy-butyrat;

Chemical Property of ETHYL 4-ETHOXYBUTYRATE

Chemical Property:

• Vapor Pressure: 0.341mmHg at 25°C
• Refractive Index: n20/D 1.413(lit.)
• Boiling Point: 183-186oC(lit.)
• Flash Point: 160 °F
• PSA: 35.53000
• Density: 0.928 g/mL at 25oC(lit.)
• LogP: 1.36620

Purity/Quality:

98%Min ^*data from raw suppliers

Ethyl 4-ethoxybutyrate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-ETHOXYBUTYRATE

There total 17 articles about ETHYL 4-ETHOXYBUTYRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-butanolide (96-48-0) + orthoformic acid triethyl ester (122-51-0) → 4-ethoxy-butyric acid ethyl ester (26448-91-9)

Guidance literature:

With sulfuric acid; In ethanol; at 50 ℃; for 12h; Cooling with ice;

Reference yield: 75.0%

ethanol (64-17-5) + 1-ethoxy-3-iodopropane (123691-74-7) + carbon monoxide (201230-82-2) → 4-ethoxy-butyric acid ethyl ester (26448-91-9)

Guidance literature:

With 4 A molecular sieve; dicobalt octacarbonyl; In tetrahydrofuran; at 100 ℃; for 48h; under 38000 Torr;

DOI:10.1016/S0040-4039(00)92294-9

Reference yield: 56.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 3-ethoxypropyl methanesulfonate (135679-22-0) → 4-ethoxy-butyric acid ethyl ester (26448-91-9)

Guidance literature:

With sodium iodide; dicobalt octacarbonyl; In various solvent(s); at 100 ℃; for 24h; under 38000 Torr;

DOI:10.1016/0040-4039(91)80697-5

upstream raw materials:

4-butanolide

triethyloxonium fluoroborate

2,2-diethoxytetrahydrofuran

ethanol

Downstream raw materials:

4-ethoxybutan-1-ol

4-ethoxybutanoic acid

butylene glycol monoethyl ether acetate

Refernces

• 1、 -. "COMPOSITIONS, SYNTHESIS, AND METHODS OF USING PHENYLCYCLOALKYLMETHYLAMINE DERIVATIVES". Page/Page column 55. . Retrieved 2013/07/19.
• 2、 Urata, Hisao,Hu, Nan-Xing,Maekawa, Hisayuki,Fuchikami, Takamasa. "TRANSITION METAL COMPLEX CATALYZED CARBONYLATION OF ORGANIC HALIDES IN THE PRESENCE OF MOLECULAR SIEVES INSTEAD OF BASE". . p. 4733 - 4736. Retrieved 2007/10/02.