Eperisone

Base Information

• Chemical Name: Eperisone
• CAS No.: 64840-90-0
• Deprecated CAS: 124308-54-9
• Molecular Formula: C17H25NO
• Molecular Weight: 259.392
• Hs Code.: 2933399090
• UNII: 2M2P0551D3
• DSSTox Substance ID: DTXSID5040671
• Nikkaji Number: J32.876F
• Wikipedia: Eperisone
• Wikidata: Q426401
• NCI Thesaurus Code: C83692
• Pharos Ligand ID: TUD5VVMVKLW2
• Metabolomics Workbench ID: 152066
• ChEMBL ID: CHEMBL1902981
• Mol file: 64840-90-0.mol

Synonyms:(4'-ethyl-2-methyl-3-piperidino)propiophenone;4-EMPP;E-0646;eperisone

Chemical Property of Eperisone

Chemical Property:

• Melting Point: 170-172oC
• Boiling Point: 386.8 °C at 760 mmHg
• Flash Point: 137.4 °C
• PSA: 20.31000
• Density: 0.994 g/cm³
• LogP: 3.49160
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 259.193614421
• Heavy Atom Count: 19
• Complexity: 275

Purity/Quality:

99% ^*data from raw suppliers

Eperisone 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2
• Recent ClinicalTrials: Radial Extracorporeal Shock Wave Therapy for Chronic Non-specific Low Back Pain
• Recent EU Clinical Trials: A pilot, prospective, randomized, open, blinded end point, phase II study of tolerability and efficacy of Eperisone in Amyotrophic Lateral Sclerosis
• Recent NIPH Clinical Trials: Clinical study for companion diagnostics for type 2 diabetes (T2DM) with aberrant tRNA modification.
• Description: Apiresone is a central skeletal muscle relaxant with various pharmacological effects. Animal experiments suggest that eperisone hydrochloride can dose-dependently inhibit decerebral tonic (γ-rigid) and ischemic decerebral tonic (α-rigid) induced by interthalamic transection in rats, and inhibit the stimulation of the dorsal spinal cord in cats with spinal cord injury. The evoked monosynaptic and polysynaptic reflex potentials may reduce the sensitivity of muscle spindles by inhibiting the γ-neuron system.
• Therapeutic Function: Muscle relaxant

Technology Process of Eperisone

There total 3 articles about Eperisone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

eperisone hydrochloride (56839-43-1) → eperisone (64840-90-0,163437-01-2)

Guidance literature:

With sodium hydrogencarbonate; In water; ethyl acetate; Product distribution / selectivity;

Reference yield: 29.0%

piperidine (110-89-4) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-(4-ethylphenyl)-1-propanone (27465-51-6) → eperisone (64840-90-0,163437-01-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃; for 36h; Sealed tube; Reflux;

Reference yield:

→ eperisone (64840-90-0,163437-01-2)

Guidance literature:

4-Ethylpropiophenon, Paraformaldehyd, Piperidin-hydrochlorid / Δ;

upstream raw materials:

eperisone hydrochloride

piperidine

formaldehyd

1-(4-ethylphenyl)-1-propanone

Downstream raw materials:

(2RS)-1-(4-ethylphenyl)-2-methyl-3-piperidin-1-yl-propan-1-one fumarate

(2RS)-1-(4-ethylphenyl)-2-methyl-3-piperidin-1-yl-propan-1-one succinate

(-)-Eperisone

(+)-Eperisone

Refernces

• 1、 -. "NOVEL FORMS OF EPERISONE". Page/Page column 33. . Retrieved 2010/08/04.