2-METHYLGLUTARIC ACID

Base Information

• Chemical Name: 2-METHYLGLUTARIC ACID
• CAS No.: 18069-17-5
• Molecular Formula: C6H10O4
• Molecular Weight: 146.143
• Hs Code.: 29171990
• Mol file: 18069-17-5.mol

Synonyms:2-Methylglutaric acid;2-Methylpentanedioic acid;

Chemical Property of 2-METHYLGLUTARIC ACID

Chemical Property:

• Appearance/Colour: white to almost white fine crystalline powder
• Vapor Pressure: 2.76E-05mmHg at 25°C
• Melting Point: 80-82 °C(lit.)
• Refractive Index: 1.4336 (estimate)
• Boiling Point: 332.7 °C at 760 mmHg
• Flash Point: 148.8 °C
• PSA: 74.60000
• Density: 1.246 g/cm³
• LogP: 0.57190

Purity/Quality:

98% ^*data from raw suppliers

2-Methylglutaric acid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Methylglutaric acid was used in the preparation of acetic acid.

Technology Process of 2-METHYLGLUTARIC ACID

There total 102 articles about 2-METHYLGLUTARIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-methylglutaronitrile (4553-62-2) → 2-methylglutaric acid (18069-17-5)

Guidance literature:

With sulfuric acid; nitric acid; at 90 ℃; for 16h; Reagent/catalyst; Temperature; Inert atmosphere;

Reference yield:

2H-pyran-2-one-5-carboxylic acid (500-05-0) → 6-oxo-tetrahydro-pyran-3-carboxylic acid (5807-38-5) + 2-methylglutaric acid (18069-17-5)

Guidance literature:

With methanol; palladium on activated charcoal; Hydrogenation;

DOI:10.1021/ja01613a101

Reference yield:

methyl coumalate (6018-41-3) → 2-methylglutaric acid (18069-17-5)

Guidance literature:

With methanol; platinum(IV) oxide; Hydrogenation_.Verseifung der NaHCO₃-loeslichen Anteile des Reaktionsprodukts mit konz. HCl;

DOI:10.1021/jo01204a010

upstream raw materials:

2H-pyran-2-one-5-carboxylic acid

methyl coumalate

2,6-dimethyl-5-oxo-heptanoic acid

chloroform

Downstream raw materials:

diethyl 2-methylglutarate

acetone

2-bromo-4-methyl-glutaric acid dimethyl ester

N,N'-diphenyl-2-methylpentane-1,5-dicarboxamide

Refernces

• 1、 Yoneda, Norihiko,Suzuki, Akira,Takahashi, Yukio. "CARBOXYLATION OF γ-BUTYROLACTONES WITH CARBON MONOXIDE USING HF-SbF5 SUPER ACID". . p. 767 - 768. Retrieved 1981.
• 2、 Beller, Matthias,Ge, Yao,Huang, Weiheng,Jackstell, Ralf,Liu, Jiawang,Neumann, Helfried,Yang, Ji. "Direct and Selective Synthesis of Adipic and Other Dicarboxylic Acids by Palladium-Catalyzed Carbonylation of Allylic Alcohols". supporting information. p. 20394 - 20398. Retrieved 2020/09/21.
• 3、 -. "PRODUCTION OF A COMPOUND COMPRISING AT LEAST ONE CARBOXYLIC ACID FUNCTIONAL GROUP". Page/Page column 21; 22. . Retrieved 2015/07/15.