Glucagon

Base Information

• Chemical Name: Glucagon
• CAS No.: 9007-92-5
• Deprecated CAS: 12709-67-0,37307-57-6,82905-30-4,37328-81-7,11025-50-6,17084-65-0,35-25-6,81217-71-2,1015835-34-3,1355953-05-7
• Molecular Formula: C153H226ClN43O49S
• Molecular Weight: 3480.62
• European Community (EC) Number: 232-708-2
• DSSTox Substance ID: DTXSID101016809
• NCI Thesaurus Code: C520
• RXCUI: 4832
• Wikipedia: Glucagon
• Mol file: 9007-92-5.mol

Synonyms:big plasma glucagon;glucagon-like-immunoreactivity;gut glucagon-like immunoreactants;Glucagon;Glucagon (1-29);Glukagon;HG Factor;HG-Factor;Hyperglycemic Glycogenolytic Factor;Hyperglycemic-Glycogenolytic Factor;Proglucagon (33-61)

Chemical Property of Glucagon

Chemical Property:

• Melting Point: -15oC
• Boiling Point: 230oC at 760 mm Hg
• PSA: 1564.04000
• LogP: 0.39110
• Storage Temp.: 2-8°C
• XLogP3: -16.9
• Hydrogen Bond Donor Count: 55
• Hydrogen Bond Acceptor Count: 55
• Rotatable Bond Count: 115
• Exact Mass: 3481.6190567
• Heavy Atom Count: 246
• Complexity: 8160

Purity/Quality:

99%, ^*data from raw suppliers

Glucagon, Human ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(CCSC)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)O)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC6=CC=CC=C6)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)N)NC(=O)C(CO)NC(=O)C(CC7=CN=CN7)N
• Isomeric SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC5=CNC6=CC=CC=C65)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC7=CN=CN7)N)O
• Recent ClinicalTrials: Pancreatic Clamp in NAFLD
• Recent EU Clinical Trials: A stable glucagon analog administered by a bihormonal closed loop system; a feasibility study
• Recent NIPH Clinical Trials: Prospective observational study on image quality and diagnostic ability evaluation by glucagon administration during prostate MRI scan
• Description: GlucaGon, a recombinant DNA product, was developed as a nasal formulation of glucagon for the treatment of insulin-induced hypoglycemia. Glucagon is widely used by insulin dependent diabetic patients as an emergency treatment for severe hypoglycemic reactions. Use of genetically engineered glucagon by both intranasal and intramuscular methods has a similar effect on hepatic glucose production rate as natural glucagon from pancreatic extraction.
• Uses: Glucagon is a hormone secreted by the pancreas that raises blood glucose levels. Glucagon is released by the pancreas when blood sugar (glucose) levels fall too low. Glucagon causes the liver to convert stored glycogen into glucose thus increasing glucose levels and having the opposite effect of insulin.