2,4-Diiodoanisole

Base Information

• Chemical Name: 2,4-Diiodoanisole
• CAS No.: 28896-47-1
• Molecular Formula: C7H6I2O
• Molecular Weight: 359.933
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID10409242
• Nikkaji Number: J628.784K
• Wikidata: Q82214983
• Mol file: 28896-47-1.mol

Synonyms:2,4-Diiodoanisole;2,4-diiodo-1-methoxybenzene;28896-47-1;2,4-di-iodo-anisole;SCHEMBL482383;DTXSID10409242;OTAQXBOSFMHIBN-UHFFFAOYSA-N;AKOS016032120;AT18541;FT-0724236

Chemical Property of 2,4-Diiodoanisole

Chemical Property:

• PSA: 9.23000
• LogP: 2.90440
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 359.85081
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

98% ^*data from raw suppliers

1-METHOXY-2,4-DIIODOBENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)I)I

Technology Process of 2,4-Diiodoanisole

There total 33 articles about 2,4-Diiodoanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methoxybenzene (100-66-3) → 2,4-diiodoanisole (28896-47-1)

Guidance literature:

With poly; iodine; In ethyl acetate; at 60 ℃; for 16h;

DOI:10.1055/s-1998-1713

Reference yield: 92.0%

4-methoxybenzoic acid (100-09-4) → 2,4-diiodoanisole (28896-47-1)

Guidance literature:

With [bis(acetoxy)iodo]benzene; lithium iodide; In 1,1,1,3,3,3-hexafluoroisopropanol; at 20 ℃; for 3h;

DOI:10.1055/s-0030-1260791

Reference yield: 89.0%

para-iodoanisole (696-62-8) → 2,4-diiodoanisole (28896-47-1)

Guidance literature:

With [bis(acetoxy)iodo]benzene; lithium iodide; In 1,1,1,3,3,3-hexafluoroisopropanol; at 50 ℃; for 1h;

DOI:10.1055/s-0030-1260791

upstream raw materials:

2,4-diiodophenol

para-iodoanisole

3-iodo-4-methoxyaniline

3-amino-4-methyloxyphenyliodide

Downstream raw materials:

2-allyl-4-iodo-1-methoxybenzene

4-iodo-1-methoxy-2-(3-methylbut-2-enyl)benzene

2-iodo-1-methoxy-4-nitrobenzene

Refernces

• 1、 Suzuki,Yoshida. "". . p. 287. Retrieved 1972.
• 2、 Narobe, Rok,Düsel, Simon J. S.,Iskra, Jernej,K?nig, Burkhard. "Photocatalytic Oxidative Iodination of Electron-Rich Arenes". supporting information. p. 3998 - 4004. Retrieved 2019/07/17.
• 3、 Webster, Stacey,O'Rourke, Kerry M.,Fletcher, Conor,Pimlott, Sally L.,Sutherland, Andrew,Lee, Ai-Lan. "Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes". supporting information. p. 937 - 943. Retrieved 2017/12/26.