N-(2,6-Dimethylphenyl)-2-hydroxyacetamide

Base Information

• Chemical Name: N-(2,6-Dimethylphenyl)-2-hydroxyacetamide
• CAS No.: 29183-14-0
• Molecular Formula: C10H13NO
• Molecular Weight: 179.219
• UNII: EIU92KG3IM
• DSSTox Substance ID: DTXSID50560821
• Nikkaji Number: J2.770.058F
• Wikidata: Q27277208
• Mol file: 29183-14-0.mol

Synonyms:N-(2,6-Dimethylphenyl)-2-hydroxyacetamide;29183-14-0;2',6'-Glycoloxylidide;CVT-2535;Acetamide, N-(2,6-dimethylphenyl)-2-hydroxy-;EIU92KG3IM;RS-89983;UNII-EIU92KG3IM;SCHEMBL5892506;DTXSID50560821;Ranolazine metabolite CVT-2535;CGA37734;AKOS000126091;CS-0181574;NS00014444;F20956;LID_180.1018_12.9;Q27277208

Chemical Property of N-(2,6-Dimethylphenyl)-2-hydroxyacetamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 90-91 °C
• Refractive Index: 1.593
• Boiling Point: 337.408 °C at 760 mmHg
• PKA: 13.20±0.10(Predicted)
• Flash Point: 157.859 °C
• PSA: 52.82000
• Density: 1.175 g/cm³
• LogP: 1.88370
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

N-(2,6-DIMETHYLPHENYL)-2-HYDROXYACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)C)NC(=O)CO

Technology Process of N-(2,6-Dimethylphenyl)-2-hydroxyacetamide

There total 2 articles about N-(2,6-Dimethylphenyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chloro-N-(2,6-dimethylphenyl)acetamide (1131-01-7) → CVT-2535 (29183-14-0)

Guidance literature:

With cesium formate; In methanol; for 24h; Reflux; Inert atmosphere;

DOI:10.1016/j.jorganchem.2009.06.031

Reference yield:

→ CVT-2535 (29183-14-0)

Guidance literature:

3a, Hydrolyse m. o-Phosphorsaeure;

Reference yield:

CVT-2535 (29183-14-0) + chloroformic acid ethyl ester (541-41-3) → ethoxycarbonyloxy-acetic acid-(2,6-dimethyl-anilide) (100610-32-0)

Guidance literature:

With pyridine; acetonitrile;

DOI:10.1021/ja01532a052

upstream raw materials:

2-chloro-N-(2,6-dimethylphenyl)acetamide

Downstream raw materials:

ethoxycarbonyloxy-acetic acid-(2,6-dimethyl-anilide)

Refernces