Acetic acid, [2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester

Base Information

• Chemical Name: Acetic acid, [2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester
• CAS No.: 2977-51-7
• Molecular Formula: C14H16Cl2O4
• Molecular Weight: 319.185
• Mol file: 2977-51-7.mol

Synonyms:

Chemical Property of Acetic acid, [2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester

Chemical Property:

• PSA: 52.60000
• LogP: 3.91810

Purity/Quality:

99% ^*data from raw suppliers

[2,3-Dichloro-4-(1-oxobutyl)phenoxy]-aceticAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid, [2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester

There total 2 articles about Acetic acid, [2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2',3'-dichloro-4'-hydroxybutyrophenone (2350-46-1) + ethyl bromoacetate (105-36-2) → 2,3-Dichlor-4-butyryl-phenoxyessigsaeure-aethylester (2977-51-7)

Guidance literature:

With potassium carbonate; potassium iodide;

DOI:10.3390/molecules14010019

Reference yield:

→ 2,3-Dichlor-4-butyryl-phenoxyessigsaeure-aethylester (2977-51-7)

Guidance literature:

entspr. ROH, Alkylierung;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2,3-Dichlor-4-butyryl-phenoxyessigsaeure-aethylester (2977-51-7) → ethacrynic acid (58-54-8)

Guidance literature:

formaldehyd; 2,3-Dichlor-4-butyryl-phenoxyessigsaeure-aethylester; With potassium carbonate;

With hydrogenchloride; water;

DOI:10.3390/molecules14010019

upstream raw materials:

2',3'-dichloro-4'-hydroxybutyrophenone

ethyl bromoacetate

Downstream raw materials:

ethacrynic acid

Refernces

• 1、 Dude, Marie-Adrienne,Kaeppler, Ulrich,Herb, Monika,Schiller, Markus,Schulz, Franziska,Vedder, Birgit,Heppner, Saskia,Pradel, Gabriele,Gut, Jiri,Rosenthal, Philip J.,Schirmeister, Tanja,Leippe, Matthias,Gelhaus, Christoph. "Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid". scheme or table. p. 19 - 35. Retrieved 2009/09/08.