D-LACTAL

Base Information

• Chemical Name: D-LACTAL
• CAS No.: 65207-55-8
• Molecular Formula: C12H20 O9
• Molecular Weight: 308.285
• Hs Code.: 29400090
• Mol file: 65207-55-8.mol

Synonyms:Lactal

Chemical Property of D-LACTAL

Chemical Property:

• Vapor Pressure: 1.55E-17mmHg at 25°C
• Melting Point: 196-199 °C(lit.)
• Boiling Point: 612°C at 760 mmHg
• PKA: 12.59±0.60(Predicted)
• Flash Point: 323.9°C
• PSA: 228.60000
• Density: 1.61g/cm³
• LogP: -6.60020
• Storage Temp.: ?20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

D-Lactal ^*data from reagent suppliers

Safty Information:

• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of D-LACTAL

There total 12 articles about D-LACTAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

hexa-O-acetyl-D-lactal (51450-24-9) → D-lactal (65207-55-8,5346-85-0)

Guidance literature:

With sodium carbonate; In methanol; for 2h; Ambient temperature;

DOI:10.1016/S0040-4039(99)00231-2

Reference yield: 92.0%

hexa-O-acetyl-D-lactal (51450-24-9) → penta-O-acetyl-1,5-anhydro-2-deoxy-3-hydroxy-4-O-β-galactopyranosyl-D-arabinohex-1-enitol (1180510-59-1) + D-lactal (65207-55-8,5346-85-0)

Guidance literature:

With 1-ethyl-3-methyl-1H-imidazolium methylsulfate; In acetonitrile; at 25 ℃; for 26h; pH=5; regioselective reaction; aq. acetate buffer; Enzymatic reaction;

DOI:10.1039/c003829f

Reference yield:

CDP-glucose (2906-23-2) + D-glucal (13265-84-4) → D-lactal (65207-55-8,5346-85-0)

Guidance literature:

With sodium cacodylate; manganese(ll) chloride; α-lactalbumin; at 37 ℃; for 96h; UDPGlc epimerase, galactosyltransferase (GalT);

upstream raw materials:

uridine 5'-diphospho-D-galactose

D-glucal

CDP-glucose

uridine-5'-diphosphoglucose

Downstream raw materials:

4-O-(3-O-benzyl-β-D-galactopyranosyl)-D-arabino-hex-1-enitol

4-O-(3,6-di-O-benzyl-β-D-galactopyranosyl)-D-arabino-hex-1-enitol

2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl-(1->4)-1,5-anhydro-2-deoxy-3,6-di-O-benzyl-D-arabino-hex-1-enitol

(2R,3R,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-[(2R,3S,4R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3,4-dihydro-2H-pyran-3-yloxy]-tetrahydro-pyran-3,4,5-triol

Refernces

• 1、 Wang, Zhi-Guang,Warren, J. David,Dudkin, Vadim Y.,Zhang, Xufang,Iserloh, Ulrich,Visser, Michael,Eckhardt, Matthias,Seeberger, Peter H.,Danishefsky, Samuel J.. "A highly convergent synthesis of an N-linked glycopeptide presenting the H-type 2 human blood group determinant". . p. 4954 - 4978. Retrieved 2007/10/03.
• 2、 Wang, Zhi-Guang,Zhang, Xufang,Visser, Michael,Live, David,Zatorski, Andrzej,Iserloh, Ulrich,Lloyd, Kenneth O.,Danishefsky, Samuel J.. "Toward fully synthetic homogeneous glycoproteins: A high mannose core containing glycopeptide carrying full h-type2 human blood group specificity". . p. 1728 - 1732. Retrieved 2007/10/03.