5-nitro-2,4-dimethoxypyrimidine

Base Information

• Chemical Name: 5-nitro-2,4-dimethoxypyrimidine
• CAS No.: 30561-07-0
• Molecular Formula: C6H7N3O4
• Molecular Weight: 185.13700
• Mol file: 30561-07-0.mol

Synonyms:2,4-Dimethoxy-5-nitro-pyrimidine;2,4-dimethoxy-5-nitropyrimidine;5-Nitro-2,4-dimethoxypyrimidine;2,4-Dimethoxy-5-nitro-pyrimidin;2,4-Dimethoxy-5-nitropyrimidin;

Chemical Property of 5-nitro-2,4-dimethoxypyrimidine

Chemical Property:

• PSA: 90.06000
• LogP: 0.92520
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dimethoxy-5-nitropyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-nitro-2,4-dimethoxypyrimidine

There total 4 articles about 5-nitro-2,4-dimethoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methanol (67-56-1) + 2,4-Dichloro-5-nitropyrimidine (49845-33-2) → 5-nitro-2,4-dimethoxypyrimidine (30561-07-0)

Guidance literature:

With sodium; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 69.0%

2,4-dimethoxypyrimidin-5-ylboronic acid (89641-18-9) → 5-nitro-2,4-dimethoxypyrimidine (30561-07-0)

Guidance literature:

With N–nitrosuccinimide; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; In acetonitrile; at 20 ℃; for 19h; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.0c00671

Reference yield:

2,4-Dichloro-5-nitropyrimidine (49845-33-2) → 5-nitro-2,4-dimethoxypyrimidine (30561-07-0)

Guidance literature:

With sodium methylate; sodium; In methanol;

upstream raw materials:

sodium methylate

2,4-Dichloro-5-nitropyrimidine

methanol

2,4-dimethoxypyrimidin-5-ylboronic acid

Downstream raw materials:

2,4-dimethoxypyrimidin-5-ylamine

4-chloro-2-(2,4-dimethoxy-pyrimidin-5-ylamino)-benzoic acid

1,1'-(4-hydroxy-6-methyl-1,3-phenylene)diethanone

Refernces

• 1、 -. "1,2,3',5'-TETRAHYDRO-2'H-SPIRO[INDOLE-3,1'-PYRROLO[3,4-C]PYRROLE]-2,3'-DIONE COMPOUNDS AS THERAPEUTIC AGENTS ACTIVATING TP53". Paragraph 0088-0089. . Retrieved 2019/07/24.
• 2、 -. "N-heterocyclyl sulphonamide derivatives and their use as endothelin antagonists". . . Retrieved 2008/06/13.