H-SER(TBU)-OTBU HCL

Base Information

• Chemical Name: H-SER(TBU)-OTBU HCL
• CAS No.: 51537-21-4
• Molecular Formula: C11H24ClNO3
• Molecular Weight: 253.769
• Hs Code.: 2922500090
• Mol file: 51537-21-4.mol

Synonyms:Alanine,3-tert-butoxy-, tert-butyl ester, hydrochloride (6CI,7CI);L-Serine,O-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester, hydrochloride (9CI);(S)-2-Amino-3-tert-butoxypropionic acid tert-butyl ester hydrochloride;NSC164061;O-tert-Butyl-L-serine tert-butyl ester hydrochloride;

Chemical Property of H-SER(TBU)-OTBU HCL

Chemical Property:

• Vapor Pressure: 0.0031mmHg at 25°C
• Melting Point: 170-177℃
• Refractive Index: 1.447
• Boiling Point: 318.4 °C at 760 mmHg
• Flash Point: 146.4 °C
• PSA: 61.55000
• Density: 0.969g/cm3
• LogP: 2.97280
• Storage Temp.: Store at 0-5°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

O-tert-Butyl-L-serine t-butyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of H-SER(TBU)-OTBU HCL

There total 2 articles about H-SER(TBU)-OTBU HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-L-serine 1,1-dimethylethyl ester (58455-98-4) → O-tert-butyl-L-serine tert-butyl ester hydrochloride (51537-21-4,179559-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / methanol

2: 1 M HCl / ethyl acetate / Ambient temperature

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; ethyl acetate;

DOI:10.1021/jo00090a045

Reference yield:

N-BOC-O-tert-butylserine tert-butyl ester → O-tert-butyl-L-serine tert-butyl ester hydrochloride (51537-21-4,179559-35-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate; Yield given; Ambient temperature;

DOI:10.1021/jo00090a045

Reference yield: 99.0%

(S)-3-tert-butoxycarbonylamino-4-phenylbutanoic acid (51871-62-6) + O-tert-butyl-L-serine tert-butyl ester hydrochloride (51537-21-4,179559-35-4) → Boc-L-β-HoPhe-L-Ser(t-Bu)-O-t-Bu

Guidance literature:

With pentamethoxy tantalum; 1-(Trimethylsilyl)imidazole; In neat (no solvent); at 50 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.9b08415

upstream raw materials:

O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-L-serine 1,1-dimethylethyl ester

Downstream raw materials:

N-carbobenzyloxy-L-asparaginyl-O-tert-butyl-L-serine tert-butyl ester

3-tert-butoxy-2-{2-[2,3-dichloro-4-(2-ethyl-acryloyl)-phenoxy]-acetylamino}-propionic acid tert-butyl ester

C₄₁H₄₉F₂N₃O₈S

C₄₀H₅₆N₆O₈S

Refernces