1-Phenyl-2-pyrrolidinylethylamine

Base Information

• Chemical Name: 1-Phenyl-2-pyrrolidinylethylamine
• CAS No.: 31788-83-7
• Molecular Formula: C12H18N2
• Molecular Weight: 190.28500
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70390667
• Mol file: 31788-83-7.mol

Synonyms:31788-83-7;1-Phenyl-2-pyrrolidinylethylamine;1-Phenyl-2-pyrrolidin-1-yl-ethylamine;1-phenyl-2-pyrrolidin-1-ylethanamine;1-Phenyl-2-(Pyrrolidin-1-Yl)Ethan-1-Amine;1-phenyl-2-(pyrrolidin-1-yl)ethanamine;1-Phenyl-2-pyrrolidin-1-ylethylamine;(S)-a-Phenyl-1-pyrrolidineethanamine 2HCl;SCHEMBL433071;DTXSID70390667;1-phenyl-2-1-pyrrolidinylethanamine;MFCD01862530;AKOS000138996;AKOS016042101;1-phenyl-2-(1-pyrrolidinyl)ethanamine;CS-0215886;FT-0678714;EC-000.2060;EN300-30611;Z228584858

Chemical Property of 1-Phenyl-2-pyrrolidinylethylamine

Chemical Property:

• Vapor Pressure: 0.0016mmHg at 25°C
• Boiling Point: 294.7oC at 760 mmHg
• Flash Point: 120oC
• PSA: 29.26000
• Density: 1.042g/cm3
• LogP: 2.42040
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 190.146998583
• Heavy Atom Count: 14
• Complexity: 158

Purity/Quality:

98%min ^*data from raw suppliers

1-Phenyl-2-(pyrrolidin-1-yl)ethan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)CC(C2=CC=CC=C2)N

Technology Process of 1-Phenyl-2-pyrrolidinylethylamine

There total 1 articles about 1-Phenyl-2-pyrrolidinylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

1-(2-amino-2-phenyl-ethyl)-pyrrolidin-2-one (43003-24-3) → 1-(2-Amino-2-phenyl-ethyl)pyrrolidin (31788-83-7) + 2-Phenyl-perhydropyrrolo<1,2-a>imidazol (95646-37-0)

Guidance literature:

With diisobutylaluminium hydride; at -30 ℃; Further temp. and conc.;

Reference yield: 96.4%

1-(2-Amino-2-phenyl-ethyl)pyrrolidin (31788-83-7) + acetyl chloride (75-36-5) → 1-(2-Acetylamino-2-phenylethyl)pyrrolidin (95646-43-8)

Guidance literature:

With sodium hydroxide; Ambient temperature;

Reference yield: 56.0%

1-(2-Amino-2-phenyl-ethyl)pyrrolidin (31788-83-7) → 1-(2-amino-2-phenyl-ethyl)-pyrrolidin-2-one (43003-24-3) + 2-Phenyl-perhydropyrrolo<1,2-a>imidazol (95646-37-0) + 3-phenyl-1,4-diazabicyclo[3.3.0]-4-octene (43003-43-6)

Guidance literature:

With trityl tetrafluoroborate; In acetonitrile; Product distribution; further temp., agents and diamines;

upstream raw materials:

1-(2-amino-2-phenyl-ethyl)-pyrrolidin-2-one

Downstream raw materials:

1-(2-amino-2-phenyl-ethyl)-pyrrolidin-2-one

2-Phenyl-perhydropyrrolo<1,2-a>imidazol

3-phenyl-1,4-diazabicyclo[3.3.0]-4-octene

1-(2-Acetylamino-2-phenylethyl)pyrrolidin

Refernces