5-Fluoro-2-nitro-N-phenylaniline

Base Information

• Chemical Name: 5-Fluoro-2-nitro-N-phenylaniline
• CAS No.: 322-68-9
• Molecular Formula: C12H9FN2O2
• Molecular Weight: 232.214
• Hs Code.: 2921440000
• Mol file: 322-68-9.mol

Synonyms:

Chemical Property of 5-Fluoro-2-nitro-N-phenylaniline

Chemical Property:

• Melting Point: 93-94 °C
• Boiling Point: 343.6±32.0 °C(Predicted)
• PKA: -4.30±0.50(Predicted)
• PSA: 57.85000
• Density: 1.353±0.06 g/cm3(Predicted)
• LogP: 4.07370
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Fluoro-2-nitro-N-phenylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-2-nitro-N-phenylaniline

There total 6 articles about 5-Fluoro-2-nitro-N-phenylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,4-Difluoronitrobenzene (446-35-5) + aniline (62-53-3) → 4-fluoro-2-(phenylamino)nitrobenzene (322-68-9)

Guidance literature:

aniline; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

2,4-Difluoronitrobenzene; In tetrahydrofuran; at -78 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield: 71.0%

iodobenzene (591-50-4) + 5-fluoro-2-nitroaniline (2369-11-1) → 4-fluoro-2-(phenylamino)nitrobenzene (322-68-9)

Guidance literature:

5-fluoro-2-nitroaniline; With sodium t-butanolate; In toluene; for 1h; Inert atmosphere;

iodobenzene; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In toluene; at 60 ℃; Inert atmosphere;

Reference yield: 61.0%

aniline (62-53-3) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 4-fluoro-2-(phenylamino)nitrobenzene (322-68-9)

Guidance literature:

aniline; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0166667h; Inert atmosphere;

4-Fluoronitrobenzene; In tetrahydrofuran; hexane; at -120 - -110 ℃; for 0.166667h; Inert atmosphere;

With potassium permanganate; ammonia; In tetrahydrofuran; hexane; at -110 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1039/c6cc02235a

upstream raw materials:

2,4-Difluoronitrobenzene

aniline

4-fluoro-1,2-dinitro-benzene

3-fluoro-1-nitrobenzene

Downstream raw materials:

[(S)-2-ethoxy-1-(4-fluoro-2-phenylaminophenylcarbamoyl)ethyl]carbamic acid tert-butyl ester

[(R)-1-(6-fluoro-7-methyl-1-phenyl-1H-benzoimidazol-2-yl)-2-methoxyethyl]-[9-(tetrahydropyran-2-yl)-9H-purin-6-yl]amine

[(S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]methylamine

[(S)-1-(6-fluoro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]-methyl-(9H-purin-6-yl)amine

Refernces

• 1、 Plater, M. John,Harrison, William T. A.. "An Organic Zeolite With 10 ? Diameter Pores Assembles From a Soluble and Flexible Building Block by Non-Covalent Interactions". . p. 457 - 463. Retrieved 2019.
• 2、 Zhang, Aigui,Yue, Ying,Yang, Jian,Shi, Jiaxing,Tao, Ke,Jin, Hong,Hou, Taiping. "Design, Synthesis, and Antifungal Activities of Novel Aromatic Carboxamides Containing a Diphenylamine Scaffold". . p. 5008 - 5016. Retrieved 2019/05/08.