Acetic acid, methoxy-, 1-phenylethyl ester

Base Information

• Chemical Name: Acetic acid, methoxy-, 1-phenylethyl ester
• CAS No.: 32786-26-8
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Mol file: 32786-26-8.mol

Synonyms:

Chemical Property of Acetic acid, methoxy-, 1-phenylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid, methoxy-, 1-phenylethyl ester

There total 2 articles about Acetic acid, methoxy-, 1-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Methoxyacetyl chloride (38870-89-2) + 1-Phenylethanol (98-85-1,13323-81-4) → 1-phenylethyl 2-methoxyacetate (32786-26-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.tetasy.2003.11.013

Reference yield:

→ 1-phenylethyl 2-methoxyacetate (32786-26-8)

Guidance literature:

Methyl-1-phenylethyl-diazomalonat, Photolyse, W.;

Reference yield: 67.0%

1-phenylethyl 2-methoxyacetate (32786-26-8) + 2-heptylamine (123-82-0) → (S)-1-phenylethanol (1445-91-6) + (R)-1-phenylethanol (1517-69-7) + (R)-N-(heptan-2-yl)propionamide + (S)-1-phenylethyl 2-methoxyacetate + (R)-1-phenylethyl 2-methoxyacetate

Guidance literature:

With hydrogen; lipase B from Candida antarctica; In toluene; at 70 ℃; for 48h; under 750.075 Torr; Resolution of racemate; Enzymatic reaction;

DOI:10.1002/ejoc.201400042

upstream raw materials:

Methoxyacetyl chloride

1-Phenylethanol

Downstream raw materials:

(1S,2R)-2-phenylcyclopentanamine

trans-(1R,2S)-2-phenylcyclopentylamine

(R)-1-phenylethanol

(1R,2R)-(-)-cis-2-Phenylcyclopentanamin

Refernces

• 1、 Machado, Luciana L.,Lemos, Telma L.G.,de Mattos, Marcos Carlos,de Oliveira, Maria da Conceicao F.,de Gonzalo, Gonzalo,Gotor-Fernandez, Vicente,Gotor, Vicente. "Immobilized Manihot esculenta preparation as a novel biocatalyst in the enantioselective acetylation of racemic alcohols". . p. 1418 - 1423. Retrieved 2008/12/20.