5,8-diMethyl-1,2,3,4-tetrahydronaphthalen-1-ol (en)1-Naphthalenol

Base Information

• Chemical Name: 5,8-diMethyl-1,2,3,4-tetrahydronaphthalen-1-ol (en)1-Naphthalenol
• CAS No.: 32820-12-5
• Molecular Formula: C12H16O
• Molecular Weight: 176.25500
• Mol file: 32820-12-5.mol

Synonyms:5,8-Dimethyl-1-tetralol;5,8-Dimethyl-1,4-benzodioxane;1,4-Benzodioxin,2,3-dihydro-5,8-dimethyl;5,8-Dimethyl-1,4-benzdioxan;

Chemical Property of 5,8-diMethyl-1,2,3,4-tetrahydronaphthalen-1-ol (en)1-Naphthalenol

Chemical Property:

• Boiling Point: 309.4±11.0 °C(Predicted)
• PKA: 14?+-.0.20(Predicted)
• PSA: 20.23000
• Density: 1.063±0.06 g/cm3(Predicted)
• LogP: 2.67310

Purity/Quality:

98% ^*data from raw suppliers

5,8-DIMETHYL-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,8-diMethyl-1,2,3,4-tetrahydronaphthalen-1-ol (en)1-Naphthalenol

There total 3 articles about 5,8-diMethyl-1,2,3,4-tetrahydronaphthalen-1-ol (en)1-Naphthalenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5,8-dimethyltetralone (5037-63-8) → 5,8-Dimethyl-1-tetralol (32820-12-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃;

DOI:10.1135/cccc19990533

Reference yield:

para-xylene (106-42-3) → 5,8-Dimethyl-1-tetralol (32820-12-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / AlCl₃ / 6 h / 90 °C

2: 97 percent / NaBH₄ / ethanol / 20 °C

With sodium tetrahydroborate; aluminium trichloride; In ethanol; 1: Alkylation / 2: Reduction;

DOI:10.1135/cccc19990533

Reference yield:

4-(p-xylyl)butyric acid (1453-06-1) → 5,8-Dimethyl-1-tetralol (32820-12-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / polyphosphoric acid / 2 h / 95 °C

2: 97 percent / NaBH₄ / ethanol / 20 °C

With sodium tetrahydroborate; PPA; In ethanol; 1: Cyclization / 2: Reduction;

DOI:10.1135/cccc19990533

upstream raw materials:

5,8-dimethyltetralone

para-xylene

4-(p-xylyl)butyric acid

Refernces

• 1、 Mane, Ramchandra Bhimrao,Kadam, Abhijit Jaysingrao. "A new synthesis of occidol". . p. 533 - 538. Retrieved 2007/10/03.