Phenol, 2-(1-methylethyl)-6-(2-propenyl)-

Base Information

• Chemical Name: Phenol, 2-(1-methylethyl)-6-(2-propenyl)-
• CAS No.: 3354-56-1
• Molecular Formula: C12H16O
• Molecular Weight: 176.258
• Hs Code.: 2907199090
• Mol file: 3354-56-1.mol

Synonyms:2-Isopropyl-6-allyl-phenol;

Chemical Property of Phenol, 2-(1-methylethyl)-6-(2-propenyl)-

Chemical Property:

• PSA: 20.23000
• LogP: 3.24410

Purity/Quality:

95% ^*data from raw suppliers

2-Allyl-6-isopropylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Allyl-6-isopropylphenol is an intermediate in the synthesis of Propofol (P829750) related compounds and derivatives.

Technology Process of Phenol, 2-(1-methylethyl)-6-(2-propenyl)-

There total 5 articles about Phenol, 2-(1-methylethyl)-6-(2-propenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isopropoxybenzene (2741-16-4) + allyl bromide (106-95-6) → 2-allyl-6-isopropylphenol (3354-56-1)

Guidance literature:

isopropoxybenzene; allyl bromide; With benzyl tri-n-butylammonium bromide; In dichloromethane; water; at 20 ℃; for 2h;

at 250 ℃; for 2h; Inert atmosphere;

Reference yield:

1-(1-methylethyl)-2-(2-propen-1-yloxy)benzene (942-58-5) → 2-allyl-6-isopropylphenol (3354-56-1)

Guidance literature:

With N,N-diethylaniline; at 220 ℃; for 1.33333h; Inert atmosphere;

Reference yield:

1-(1-methylethyl)-2-(2-propen-1-yloxy)benzene (942-58-5) → 2-allyl-6-isopropylphenol (3354-56-1) + 2-Isopropyl-4-allyl-phenol

Guidance literature:

at 250 ℃; for 1.5h;

DOI:10.1021/jm00186a013

upstream raw materials:

1-(1-methylethyl)-2-(2-propen-1-yloxy)benzene

2-(1-methylethyl)phenol

isopropoxybenzene

allyl bromide

Downstream raw materials:

2-(1-methylethyl)-6-propylphenol

2-isopropyl-4-allyl-6-n-propylphenol

allyl 2-isopropyl-6-n-propylphenyl ether

2-isopropyl-4,6-di-n-propylphenol

Refernces

• 1、 -. "DIPHENYL DERIVATIVE AND USES THEREOF". Paragraph 0105-0110. . Retrieved 2018/06/04.
• 2、 James, Roger,Glen, John B.. "Synthesis, Biological Evaluation, and Preliminary Structure-Activity Considerations of a Series of Alkylphenols as Intravenous Anesthetic Agents". . p. 1350 - 1357. Retrieved 2007/10/02.