Cyclobutanesulfonyl chloride

Base Information

• Chemical Name: Cyclobutanesulfonyl chloride
• CAS No.: 338453-16-0
• Molecular Formula: C4H7ClO2S
• Molecular Weight: 154.617
• Hs Code.: 2904909090
• Mol file: 338453-16-0.mol

Synonyms:CYCLOBUTANESULPHONYL CHLORIDE;Cyclobutansulfonylchlorid;

Chemical Property of Cyclobutanesulfonyl chloride

Chemical Property:

• Refractive Index: 1.4603
• Boiling Point: 217℃
• Flash Point: 85℃
• PSA: 42.52000
• Density: 1.42
• LogP: 2.18830

Purity/Quality:

99% ^*data from raw suppliers

CyclobutanesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Cyclobutanesulfonyl Chloride is used in the development of a chemical toolset for studying the paralog-specific function of IRE1.

Technology Process of Cyclobutanesulfonyl chloride

There total 5 articles about Cyclobutanesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

potassium cyclobutane-sulphonate (338457-55-9) → cyclobutanesulfonyl chloride (338453-16-0)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 20h; Heating / reflux;

Reference yield: 26.19%

Bromocyclobutane (4399-47-7) → cyclobutanesulfonyl chloride (338453-16-0)

Guidance literature:

Bromocyclobutane; With magnesium; In diethyl ether; at 25 ℃; for 1.25h; Inert atmosphere; Reflux;

With sulfuryl dichloride; In diethyl ether; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; at 42 ℃; for 0.583333h; Cooling with ice;

Reference yield:

cyclobutyllithium (72507-51-8) → cyclobutanesulfonyl chloride (338453-16-0)

Guidance literature:

With sulfuryl dichloride; In hexanes; pentantes; diethyl ether; at -40 - 0 ℃; for 1h;

upstream raw materials:

cyclobutane

Bromocyclobutane

potassium cyclobutane-sulphonate

cyclobutyllithium

Downstream raw materials:

cyclobutane-sulphonic acid 5-(2,4-diamino-pyrimidin-5-ylmethyl)-3-ethoxy-2-iodo-phenyl ester

N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)cyclobutanesulfonamide

tert-butyl 1-benzyl-7-(cyclobutanesulfonamidomethyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate

ethyl 6-(2-(tert-butoxycarbonyl-((R)-2-(3-(cyclobutanesulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-1-(tetrahydro-2H-pyran-2-yl)indazole-3-carboxylate

Refernces

• 1、 Cioffi, Christopher L.,Liu, Shuang,Wolf, Mark A.,Guzzo, Peter R.,Sadalapure, Kashinath,Parthasarathy, Visweswaran,Loong, David T. J.,Maeng, Jun-Ho,Carulli, Edmund,Fang, Xiao,Karunakaran, Kalesh,Matta, Lakshman,Choo, Sok Hui,Panduga, Shailijia,Buckle, Ronald N.,Davis, Randall N.,Sakwa, Samuel A.,Gupta, Priya,Sargent, Bruce J.,Moore, Nicholas A.,Luche, Michele M.,Carr, Grant J.,Khmelnitsky, Yuri L.,Ismail, Jiffry,Chung, Mark,Bai, Mei,Leong, Wei Yee,Sachdev, Nidhi,Swaminathan, Srividya,Mhyre, Andrew J.. "Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1". . p. 8473 - 8494. Retrieved 2016/10/03.
• 2、 -. "NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMIDES AS MEK INHIBITORS". Page/Page column 69-70. . Retrieved 2010/12/31.