Benzaldehyde, 2-(benzo[b]thien-2-ylmethyl)-

Base Information

• Chemical Name: Benzaldehyde, 2-(benzo[b]thien-2-ylmethyl)-
• CAS No.: 345621-73-0
• Molecular Formula: C16H12OS
• Molecular Weight: 252.337
• Mol file: 345621-73-0.mol

Synonyms:

Chemical Property of Benzaldehyde, 2-(benzo[b]thien-2-ylmethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzaldehyde, 2-(benzo[b]thien-2-ylmethyl)-

There total 4 articles about Benzaldehyde, 2-(benzo[b]thien-2-ylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-bromomethylbenzo[b]thiophene (10133-20-7) + 2-formylbenzene boronic acid (40138-16-7) → 2-(Benzo[b]thien-2-ylmethyl)benzaldehyde (345621-73-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; at 80 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.ultsonch.2016.07.010

Reference yield:

5-benzothiophen-2-yl-2,5-dihydrobenzofuran-2-one (79966-30-6) → 2-(Benzo[b]thien-2-ylmethyl)benzaldehyde (345621-73-0)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: lithium aluminium hydride / diethyl ether / 3 h / Heating

3: chromium trioxide-pyridine complex / pyridine / 2 h / Ambient temperature

With lithium aluminium tetrahydride; chromium trioxide pyridine; hydrogen; palladium on activated charcoal; In pyridine; diethyl ether;

Reference yield:

(2-Benzo[b]thiophen-2-ylmethyl-phenyl)-methanol → 2-(Benzo[b]thien-2-ylmethyl)benzaldehyde (345621-73-0)

Guidance literature:

With chromium trioxide pyridine; In pyridine; for 2h; Yield given; Ambient temperature;

upstream raw materials:

2-(2-benzothenyl)benzenecarboxylic acid

5-benzothiophen-2-yl-2,5-dihydrobenzofuran-2-one

2-bromomethylbenzo[b]thiophene

2-formylbenzene boronic acid

Downstream raw materials:

benzo[b]naphtho[2,3-d]thiophene

Refernces

• 1、 Tominaga, Yoshinori,Lee, Milton L.,Castle, Raymond N.. "Synthesis of Anthrathiophenes and Benzonaphthothiophenes". . p. 967 - 972. Retrieved 2007/10/02.