(1R,2R)-1-Bromo-2-iodocyclohexane

Base Information

• Chemical Name: (1R,2R)-1-Bromo-2-iodocyclohexane
• CAS No.: 34701-03-6
• Molecular Formula: C6H10BrI
• Molecular Weight: 288.954
• DSSTox Substance ID: DTXSID10503097
• Wikidata: Q82356631
• Mol file: 34701-03-6.mol

Synonyms:(1R,2R)-1-Bromo-2-iodocyclohexane;34701-03-6;trans-1-Brom-2-jodcyclohexan;DTXSID10503097

Chemical Property of (1R,2R)-1-Bromo-2-iodocyclohexane

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 287.90106
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C(C1)Br)I
• Isomeric SMILES: C1CC[C@H]([C@@H](C1)Br)I

Technology Process of (1R,2R)-1-Bromo-2-iodocyclohexane

There total 4 articles about (1R,2R)-1-Bromo-2-iodocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

cyclohexene (110-83-8) → trans-1-bromo-2-iodocyclohexane (34701-03-6)

Guidance literature:

With iodine; mercury dibromide; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1039/c39850001422

Reference yield: 56.0%

cyclohexene (110-83-8) → 1-bromo-2-iodocyclohexane (34701-03-6)

Guidance literature:

With polystyrene bound benzyltriethylammonium dibromoiodate; In dichloromethane; at 30 ℃; for 36h;

Reference yield:

1-chloro-2-iodocyclohexane (29641-86-9) → 1-bromo-2-iodocyclohexane (34701-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: alcoholic KOH-solution

2: mercury bromide; diethyl ether; iodine

With potassium hydroxide; mercury bromide; diethyl ether; iodine;

upstream raw materials:

cyclohexene

1-chloro-2-iodocyclohexane

Downstream raw materials:

cyclohexene

benzoic acid-(2-iodo-cyclohexyl ester)

cyclohexyl formate

(1R,2R)-1-acetoxy-2-iodocyclohexane

Refernces

• 1、 Barluenga, Jose,Rodriguez, Miguel A.,Campos, Pedro J.. "An Efficient Method for the Copper(II)-promoted Stereoselective Iodofunctionalization of Alkenes". . p. 2807 - 2809. Retrieved 2007/10/02.
• 2、 Barluenga, Jose,Martinez-Gallo, Jose M.,Najera, Carmen,Yus, Miguel. "The Mercury(II) Salt-Halogen Combination HgX2-Hal2: A Versatile Reagent for Stereoselective Addition of Hal-X to Alkenes". . p. 1422 - 1423. Retrieved 2007/10/02.