Pyrophosphoric acid

Base Information

• Chemical Name: Pyrophosphoric acid
• CAS No.: 2466-09-3
• Deprecated CAS: 133883-41-7,1531584-96-9
• Molecular Formula: H₄O₇P₂
• Molecular Weight: 177.975
• Hs Code.: 28092000
• European Community (EC) Number: 219-574-0
• NSC Number: 289196
• UNII: 4E862E7GRQ
• DSSTox Substance ID: DTXSID4075035
• Nikkaji Number: J43.595C
• Wikipedia: Pyrophosphoric_acid
• Wikidata: Q411092
• Pharos Ligand ID: 3HY27NH9GZ8M
• ChEMBL ID: CHEMBL1160571
• Mol file: 2466-09-3.mol

Synonyms:diphosphoric acid;H4P2O7;Na4P2O7;PPi cpd;pyrophosphate;pyrophosphoric acid

Chemical Property of Pyrophosphoric acid

Chemical Property:

• Appearance/Colour: White to very pale yellow glassy solid
• Melting Point: 61 °C
• PKA: 0.99±0.10(Predicted)
• PSA: 143.91000
• Density: 2.43 g/cm3
• LogP: -0.81160
• Storage Temp.: -20°C, Hygroscopic
• Solubility.: DMSO (Soluble)
• Water Solubility.: 709g/100mL H2O (23°C); soluble alcohol, ether [MER06]
• XLogP3: -3.2
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 177.94322646
• Heavy Atom Count: 9
• Complexity: 147

Purity/Quality:

99.9% ^*data from raw suppliers

Pyrophosphoric Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Toxic Gases & Vapors -> Acids, Inorganic
• Canonical SMILES: OP(=O)(O)OP(=O)(O)O
• Recent ClinicalTrials: Pneumococcal Conjugate Vaccine Followup
• Description: Pyrophosphoric acid, also known under the name diphosphoric acid, is colorless, odorless, hygroscopic and is soluble in water, diethyl ether and ethyl alcohol. It is produced from phosphoric acid by dehydration. Pyrophosphoric acid slowly hydrolyzes in the presence of water into phosphoric acid. H4P2O7 +H2O?2H3PO4 Upon heating, phosphoric acid loses water, being converted successively, and to some extent concurrently, into the pyro- and meta-acids: 2H3PO4?H4P2O7 +H2O nH3PO4?(HPO3)n + [H2O]n
• Physical properties: Colorless needles or liquid; hygroscopic. Crystallizes in two anhydrous forms: a metastable form melting at 54.3°C and a second and more stable form melting at 71.5°C; extremely soluble in cold water, reacting very slowly to form phosphoric acid; decomposing much faster in hot water; very soluble in alcohol and ether.
• Uses: Catalyst, manufacture of organic phosphate esters, metal treatment, stabilizer for organic per- oxides. Pyrophosphoric Acid has been shown to enhance the rate of pyrophosphate hydrolysis by nonenzymatic catlysis and by inorganic pyrophoshatase. Pyrophosphoric Acid can be used for the preparation of vanadyl pyrophosphato methoxide cluster anion. Pyrophosphoric Acid is used in anion binding of inorganic phosphates due to is ability to form complexes.

Technology Process of Pyrophosphoric acid

There total 79 articles about Pyrophosphoric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosphonic Acid (13598-36-2) + bromine (7726-95-6) → hydrogen bromide (10035-10-6,12258-64-9) + pyrophosphoric acid (14000-31-8,2466-09-3) + tetrametaphosphoric acid (13598-74-8) + trimetaphosphoric acid (13566-25-1)

Guidance literature:

In neat (no solvent); byproducts: polyphosphoric acid; react. of anhydrous H3PO3 with liquid Br2 on heating; formation of HBr, (HPO3)4, (HPO3)3, H4P2O7 and higher polyphosphoric acids; exothermic react. starting at ambient temp. after an induction period;;

Reference yield:

UTP (63-39-8) + α-D-glucopyranosyl-1-phosphate (59-56-3,27251-84-9,63779-58-8,262856-84-8) → UDP-glucose (133-89-1) + pyrophosphoric acid (14000-31-8,2466-09-3)

Guidance literature:

With Cps₂L thymidylyltransferase cloned from Streptococcus pneumoniae; inorganic phosphatase; magnesium chloride; In aq. buffer; pH=7.4; Kinetics; Enzymatic reaction;

DOI:10.1039/c3ob41017j

Reference yield:

(NO)2P8O21 → dinitrogen trioxide (10544-73-7,96607-26-0) + phosphoric acid (86119-84-8,7664-38-2) + cis-nitrous acid (7782-77-6) + pyrophosphoric acid (14000-31-8,2466-09-3)

Guidance literature:

With water; In water; byproducts: triphosphoric acid, tetraphosphoric acid; hydrolysis;; phosphoric acids detected by paper chromatography;;

upstream raw materials:

phosphorus(III) oxide

water

phosphorus pentoxide

phosphonic Acid

Downstream raw materials:

bromofluoroacetonitrile

Refernces

• 1、 Filippov, Ya. Yu.,Gavlina, O. T.,Kiselev, A. S.,Safronova, T. V.,Shatalova, T. B.. "Synthesis of double ammonium’calcium pyrophosphate monohydrate Ca(NH4)2P2O7?H2O as the p recursor of biocompatible phases of calcium phosphate ceramics". . p. 139 - 147. Retrieved 2020/04/21.
• 2、 Forget, Stephanie M.,Smithen, Deborah A.,Jee, Alison,Jakeman, David L.. "Mechanistic evaluation of a nucleoside tetraphosphate with a thymidylyltransferase". . p. 1703 - 1707. Retrieved 2015/04/27.