3-Morpholinoacrylaldehyde

Base Information

• Chemical Name: 3-Morpholinoacrylaldehyde
• CAS No.: 34900-00-0
• Molecular Formula: C7H11NO2
• Molecular Weight: 141.17
• Mol file: 34900-00-0.mol

Synonyms:3t-morpholino-acrylaldehyde;β-morpholinoacrolein;3t-Morpholino-acrylaldehyd;(E)-3-Morpholino-2-propenal;

Chemical Property of 3-Morpholinoacrylaldehyde

Chemical Property:

• Boiling Point: 251.4±40.0 °C(Predicted)
• PKA: 3.52±0.50(Predicted)
• PSA: 29.54000
• Density: 1.159±0.06 g/cm3(Predicted)
• LogP: -0.03090

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Morpholinoacrylaldehyde

There total 5 articles about 3-Morpholinoacrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

morpholine (110-91-8,99108-56-2) + Propargylic aldehyde (624-67-9) → 3-(3-oxapentane-1,5-diyl)aminoacrylaldehyde (34900-00-0,675610-32-9)

Guidance literature:

In diethyl ether; 1.) (-5 to -10) deg C to 20 deg C, 2.) reflux, 1 h;

Reference yield: 67.0%

morpholine (110-91-8,99108-56-2) + 1,2,3-triazine (289-96-3) → 3-(3-oxapentane-1,5-diyl)aminoacrylaldehyde (34900-00-0,675610-32-9)

Guidance literature:

With water; In tetrahydrofuran; for 24h;

DOI:10.1021/acs.orglett.7b01543

Reference yield: 19.0%

morpholine (110-91-8,99108-56-2) + Malondialdehyde (542-78-9) → 3-(3-oxapentane-1,5-diyl)aminoacrylaldehyde (34900-00-0,675610-32-9)

Guidance literature:

In various solvent(s); at 37 ℃; for 24h; pH = 5;

upstream raw materials:

morpholine

Propargylic aldehyde

Malondialdehyde

N-prop-2-ynylmorpholine N-oxide

Refernces

• 1、 Qui?ones, Ryan E.,Glinkerman, Christopher M.,Zhu, Kaicheng,Boger, Dale L.. "Direct Synthesis of β-Aminoenals through Reaction of 1,2,3-Triazine with Secondary Amines". supporting information. p. 3568 - 3571. Retrieved 2017/07/17.
• 2、 Quast, Helmut,Hergenroether, Thomas. "5-Alkylidene-4,5-dihydro-1H-tetrazoles Substituted by Vinyl or Phenyl Groups". . p. 581 - 590. Retrieved 2007/10/02.