Iododimethylarsine

Base Information

• Chemical Name: Iododimethylarsine
• CAS No.: 676-75-5
• Molecular Formula: C2H6 As I
• Molecular Weight: 231.896
• European Community (EC) Number: 211-630-2
• DSSTox Substance ID: DTXSID70217921
• Nikkaji Number: J205.975D
• Wikidata: Q83094629
• Mol file: 676-75-5.mol

Synonyms:Iododimethylarsine;676-75-5;iodo(dimethyl)arsane;Dimethyliodoarsine;Arsinous iodide, dimethyl-;CCRIS 9114;Dimethylarsenic iodide;EINECS 211-630-2;dimethylarsinous iodide;Arsinous iodide,dimethyl- (9CI);DIMETHYLARSENICIODIDE;C2H6AsI;C2-H6-As-I;SCHEMBL3065411;Arsinous iodide,dimethyl-(9ci);DTXSID70217921;AKOS027382476;LS-21849;FT-0667474

Chemical Property of Iododimethylarsine

Chemical Property:

• Vapor Pressure: 10.4mmHg at 25°C
• Boiling Point: 133.4 °C at 760 mmHg
• Flash Point: 45.1 °C
• PSA: 0.00000
• LogP: 1.67250
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 231.87302
• Heavy Atom Count: 4
• Complexity: 13.5

Purity/Quality:

99%, ^*data from raw suppliers

Dimethyliodoarsine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[As](C)I
• Uses: Dimethyliodoarsine is a dimethylated metabolite of Arsenic Trioxide that acts as a more potent growth inhibitor and apoptotic inducer in NB4 cells, an APL cell line. Dimethyliodoarsine is an arsenite metabolite in wild type CHO cells and in cells deficient in excision repair cross-complementing 1 and 2. Dimethyliodoarsine is also an inhibitor of Thioredoxin reductase, an enzyme involved in the response of the cell to oxidative stress.

Technology Process of Iododimethylarsine

There total 23 articles about Iododimethylarsine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Dimethylarsinic acid (75-60-5) → dimethyliodoarsine (676-75-5)

Guidance literature:

With sulfuric acid; sulfur dioxide; potassium iodide; In water; for 3h;

DOI:10.1021/tx960139g

Reference yield: 54.0%

sodium cacodylate (124-65-2) → dimethyliodoarsine (676-75-5)

Guidance literature:

With hydrogenchloride; sulfur dioxide; potassium iodide; In water; for 2h;

DOI:10.1016/j.tetlet.2016.12.040

Reference yield: 22.0%

triphenyl phosphite (101-02-0) + dimethylarsinosulfenyl iodide → dimethyliodoarsine (676-75-5) + O,O,O-triphenyl phosphorothioate (597-82-0)

Guidance literature:

In chloroform-d1; for 6h;

DOI:10.1002/zaac.201500096

upstream raw materials:

dimethylarsine

acetyl iodide

Dimethylchloroarsine

bis-{dimethylarsenic}-oxide

Downstream raw materials:

o-(CH₃)2AsC₆H₄N(CH₃)2

(CH₃)2As{p-C₆H₄N(CH₃)2}

diphenyl-(2-dimethylarsino-phenyl)-arsine

As,As-diethyl-As',As'-dimethyl-As,As'-o-phenylene-di-arsine

Refernces

• 1、 Styblo, Miroslav,Serves, Spiros V.,Cullen, William R.,Thomas, David J.. "Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols". . p. 27 - 33. Retrieved 1997.
• 2、 Guttenberger, Nikolaus,Sagmeister, Peter,Glabonjat, Ronald A.,Hirner, Stefan,Francesconi, Kevin A.. "Facile access to arsenic-containing triacylglycerides". supporting information. p. 362 - 364. Retrieved 2017/01/03.