7-(PHENYLMETHOXY)-1H-INDAZOLE

Base Information

• Chemical Name: 7-(PHENYLMETHOXY)-1H-INDAZOLE
• CAS No.: 351210-09-8
• Molecular Formula: C14H12N2O
• Molecular Weight: 224.25800
• Hs Code.: 2933990090
• Mol file: 351210-09-8.mol

Synonyms:

Chemical Property of 7-(PHENYLMETHOXY)-1H-INDAZOLE

Chemical Property:

• Boiling Point: 422.4±20.0 °C(Predicted)
• PKA: 13.16±0.40(Predicted)
• PSA: 37.91000
• Density: 1.247±0.06 g/cm3(Predicted)
• LogP: 3.14190
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

7-(Benzyloxy)-1H-indazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-(PHENYLMETHOXY)-1H-INDAZOLE

There total 6 articles about 7-(PHENYLMETHOXY)-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

7-hydroxy-1H-indazole (81382-46-9) + benzyl bromide (100-39-0) → 7-benzyloxyindazole (351210-09-8)

Guidance literature:

With potassium carbonate; In acetone; for 3h; Heating;

DOI:10.1016/S0960-894X(01)00156-1

Reference yield:

7-benzyloxy-3-trimethylsilanyl-1H-indazole → 7-benzyloxyindazole (351210-09-8)

Guidance literature:

With potassium hydroxide; In ethanol;

DOI:10.1016/j.tetlet.2003.12.086

Reference yield:

2-fluorophenyl phenylmethyl ether (368-21-8) → 7-benzyloxyindazole (351210-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium tetramethylpiperidine / hexane; diethyl ether / 0.25 h / -78 °C

1.2: hexane; diethyl ether / 8.5 h / Heating

2.1: KOH / ethanol

With potassium hydroxide; 2,2,6,6-tetramethylpiperidinyl-lithium; In diethyl ether; ethanol; hexane;

DOI:10.1016/j.tetlet.2003.12.086

upstream raw materials:

7-hydroxy-1H-indazole

benzyl bromide

2-fluorophenyl phenylmethyl ether

7-methoxy-1H-indazole

Refernces

• 1、 Schumann, Pascale,Collot, Valerie,Hommet, Yannick,Gsell, Willy,Dauphin, Francois,Sopkova, Jana,MacKenzie, Eric T.,Duval, Dominique,Boulouard, Michel,Rault, Sylvain. "Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles". . p. 1153 - 1156. Retrieved 2007/10/03.