tert-Butyl 4-bromo-3,5-dimethylphenylcarbamate

Base Information

• Chemical Name: tert-Butyl 4-bromo-3,5-dimethylphenylcarbamate
• CAS No.: 361436-27-3
• Molecular Formula: C13H18BrNO2
• Molecular Weight: 300.19200
• Hs Code.: 2924299090
• Mol file: 361436-27-3.mol

Synonyms:tert-butyl 4-bromo-3,5-dimethylphenylcarbamate;N-Boc 4-bromo-3,5-dimethylaniline;

Chemical Property of tert-Butyl 4-bromo-3,5-dimethylphenylcarbamate

Chemical Property:

• Boiling Point: 312.6±42.0 °C(Predicted)
• PKA: 12.99±0.70(Predicted)
• PSA: 38.33000
• Density: 1.321±0.06 g/cm3(Predicted)
• LogP: 4.48590
• Storage Temp.: Room temperature.

Purity/Quality:

98% ^*data from raw suppliers

N-Boc4-bromo-3,5-dimethylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-bromo-3,5-dimethylphenylcarbamate

There total 2 articles about tert-Butyl 4-bromo-3,5-dimethylphenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-bromo-3,5-dimethylphenol (7463-51-6) → tert-butyl (4-bromo-3,5-dimethylphenyl)carbamate (361436-27-3)

Guidance literature:

With pyridine; dmap; In dichloromethane; for 20h; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.1c03926

Reference yield:

di-tert-butyl pyrocarbamate + 4-bromo-3,5-dimethylaniline (59557-90-3) → tert-butyl (4-bromo-3,5-dimethylphenyl)carbamate (361436-27-3)

Guidance literature:

In tetrahydrofuran;

Reference yield: 97.0%

methyl iodide (74-88-4) + tert-butyl (4-bromo-3,5-dimethylphenyl)carbamate (361436-27-3) → tert-butyl (4-bromo-3,5-dimethylphenyl)(methyl)carbamate

Guidance literature:

tert-butyl (4-bromo-3,5-dimethylphenyl)carbamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.0833333h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00182

upstream raw materials:

4-bromo-3,5-dimethylaniline

di-tert-butyl dicarbonate

4-bromo-3,5-dimethylphenol

Downstream raw materials:

(4-{[1-(tert-butyl-dimethyl-silanyl)-3-isopropyl-1H-indol-5-yl]-hydroxy-methyl}-3,5-dimethyl-phenyl)-carbamic acid tert-butyl ester

tert-butyl 4-[[3-(4-fluorobenzyl)-4-methoxyphenyl](hydroxy)methyl]-3,5-dimethylphenylcarbamate

tert-butyl 4-[hydroxy(4-methoxy-3-isopropylphenyl)methyl]-3,5-dimethylphenylcarbamate

Refernces

• 1、 -. "Diphenylmethane derivatives". . . Retrieved 2008/06/13.