5-Bromo-6-methoxyisoquinoline

Base Information

• Chemical Name: 5-Bromo-6-methoxyisoquinoline
• CAS No.: 366445-82-1
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.08100
• Mol file: 366445-82-1.mol

Synonyms:

Chemical Property of 5-Bromo-6-methoxyisoquinoline

Chemical Property:

• PSA: 22.12000
• LogP: 3.00590

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-6-methoxyisoquinoline

There total 2 articles about 5-Bromo-6-methoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

6-methoxyisoquinoline (52986-70-6) → 5-bromo-6-methoxyisoquinoline (366445-82-1)

Guidance literature:

6-methoxyisoquinoline; With sulfuric acid; at 0 ℃;

With N-Bromosuccinimide; at -25 - -18 ℃; for 5h;

With ammonia; In water; pH=9;

Reference yield:

→ 5-bromo-6-methoxyisoquinoline (366445-82-1)

Guidance literature:

Reference yield:

5-bromo-6-methoxyisoquinoline (366445-82-1) → 5-bromo-6-methoxyisoquinoline-N-oxide hydrochloride (940890-88-0)

Guidance literature:

5-bromo-6-methoxyisoquinoline; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 3h;

With hydrogenchloride; In methanol; diethyl ether; dichloromethane;

upstream raw materials:

6-methoxyisoquinoline

Downstream raw materials:

5-bromo-6-methoxyisoquinoline-N-oxide hydrochloride

Refernces

• 1、 -. "MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS". Page/Page column 75. . Retrieved 2008/06/13.
• 2、 -. "Isoquinoline derivatives". Page/Page column 15. . Retrieved 2008/06/13.