Phenylacetyl fluoride

Base Information

• Chemical Name: Phenylacetyl fluoride
• CAS No.: 370-84-3
• Molecular Formula: C8H7FO
• Molecular Weight: 138.141
• Hs Code.: 2916399090
• Mol file: 370-84-3.mol

Synonyms:Phenyl-acetylfluorid;Phenylessigsaeurefluorid;phenyl-acetyl fluoride;

Chemical Property of Phenylacetyl fluoride

Chemical Property:

• PSA: 17.07000
• LogP: 1.72520

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenylacetyl fluoride

There total 24 articles about Phenylacetyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

phenylacetyl chloride (103-80-0) → phenylacetyl fluoride (370-84-3)

Guidance literature:

With potassium hydrogenfluoride; tetrabutyl-ammonium chloride; water; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1055/a-1649-5460

Reference yield: 13.5%

phenylacetaldehyde (122-78-1) → benzyl fluoride (350-50-5) + phenylacetyl fluoride (370-84-3)

Guidance literature:

With caesium fluoroxysulphate; In acetonitrile; at 35 ℃; for 1.5h;

DOI:10.1021/jo00046a013

Reference yield: 10.0%

2-phenylethanol (60-12-8) → benzyl fluoride (350-50-5) + phenylacetyl fluoride (370-84-3)

Guidance literature:

With caesium fluoroxysulphate; In acetonitrile; at 30 - 35 ℃; for 1h;

DOI:10.1021/jo962424a

upstream raw materials:

sodium phenylacetate

phenylacetyl chloride

phenylacetic acid

phenylacetylene

Downstream raw materials:

N-benzylphenylacetamide

(3S,5S,7S)-adamantan-1-yl 2-phenylacetate

benzyl 2-phenylacetate

(S)-2-[(S)-1-((S)-2-Oxo-1-phenyl-2-pyrrolidin-1-yl-ethyl)-allyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 Lee, Hyo-Jun,Huang, Xiao,Sakaki, Shigeyoshi,Maruoka, Keiji. "Metal-free approach for hindered amide-bond formation with hypervalent iodine(iii) reagents: application to hindered peptide synthesis". . p. 848 - 855. Retrieved 2021/02/09.
• 2、 Munoz, Socrates B.,Dang, Huong,Ispizua-Rodriguez, Xanath,Mathew, Thomas,Prakash, G.K. Surya. "Direct Access to Acyl Fluorides from Carboxylic Acids Using a Phosphine/Fluoride Deoxyfluorination Reagent System". supporting information. . Retrieved 2019/03/19.