3′-AMino-4′-broMoacetophenone

Base Information

• Chemical Name: 3′-AMino-4′-broMoacetophenone
• CAS No.: 37148-51-9
• Molecular Formula: C8H8BrNO
• Molecular Weight: 214.062
• Hs Code.: 2922399090
• Mol file: 37148-51-9.mol

Synonyms:1-(3-amino-4-bromo-phenyl)-ethanone;3 inverted exclamation marka-Amino-4 inverted exclamation marka-bromoacetophenone;1-(3-Amino-4-brom-phenyl)-aethanon;4-Brom-3-amino-acetophenon;5-Acetyl-2-bromoaniline;3'-amino-4'-bromoacetophenone;

Chemical Property of 3′-AMino-4′-broMoacetophenone

Chemical Property:

• Melting Point: 114-118°C
• PSA: 43.09000
• LogP: 2.81510

Purity/Quality:

99% ^*data from raw suppliers

3''-Amino-4''-Bromoacetophenone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3′-AMino-4′-broMoacetophenone

There total 7 articles about 3′-AMino-4′-broMoacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitro-4-bromoacetophenone (18640-58-9) → 3'-amino-4'-bromoacetophenone (37148-51-9)

Guidance literature:

With hydrogenchloride; tin(ll) chloride;

Reference yield:

3-nitro-4-bromoacetophenone (18640-58-9) + stannous chloride (7772-99-8) + sodium hydrogencarbonate (144-55-8) → 3'-amino-4'-bromoacetophenone (37148-51-9)

Guidance literature:

With hydrogenchloride; In methanol;

Reference yield:

para-bromoacetophenone (99-90-1) → 3'-amino-4'-bromoacetophenone (37148-51-9)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid / <0

2: tin (II)-chloride

3: hydrochloric acid

With hydrogenchloride; nitric acid; tin(ll) chloride;

DOI:10.1039/jr9310002388

upstream raw materials:

3-nitro-4-bromoacetophenone

bromobenzene

1.4-dibromobenzene

para-bromoacetophenone

Downstream raw materials:

5-ethyl-2-bromo-aniline

1-(3-amino-4-((4-methoxyphenyl)thio)phenyl)ethan-1-one

Refernces

• 1、 -. "SUBSTITUTED BICYCLIC HCV INHIBITORS". Page/Page column 37-38. . Retrieved 2010/11/03.
• 2、 -. "Tricyclic compounds and drug compositions containing the same". . . Retrieved 2008/06/13.