Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]-

Base Information

• Chemical Name: Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]-
• CAS No.: 376347-09-0
• Molecular Formula: C8H11NO3S
• Molecular Weight: 201.246
• Mol file: 376347-09-0.mol

Synonyms:N-(3-hydroxy methyl-phenyl)methanesulfonamide;[3-(hydroxymethyl)phenyl](methylsulfonyl)amine;

Chemical Property of Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]-

Chemical Property:

• PSA: 74.78000
• LogP: 1.70420

Purity/Quality:

99% ^*data from raw suppliers

N-(3-(Hydroxymethyl)phenyl)methanesulfonamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]-

There total 3 articles about Methanesulfonamide, N-[3-(hydroxymethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 3-(methylsulfonamido)benzoate (93884-11-8) → N-(3-hydroxymethylphenyl)methanesulfonamide (376347-09-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 81.0%

3-methanesulfonylaminobenzoic acid methyl ester (32087-05-1) → N-(3-hydroxymethylphenyl)methanesulfonamide (376347-09-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

Methyl 3-aminobenzoate (4518-10-9) → N-(3-hydroxymethylphenyl)methanesulfonamide (376347-09-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dichloromethane / 17 h / 25 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 25 °C / Inert atmosphere

With lithium aluminium tetrahydride; In tetrahydrofuran; pyridine; dichloromethane;

DOI:10.1002/cmdc.201500235

upstream raw materials:

ethyl 3-(methylsulfonamido)benzoate

3-methanesulfonylaminobenzoic acid methyl ester

Methyl 3-aminobenzoate

Downstream raw materials:

m-(methylsulfonylamino)benzaldehyde

Refernces

• 1、 -. "HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS". Page/Page column 119. . Retrieved 2008/12/05.