4-Piperidinoaniline

Base Information

• Chemical Name: 4-Piperidinoaniline
• CAS No.: 2359-60-6
• Molecular Formula: C11H16N2
• Molecular Weight: 176.261
• Hs Code.: 29333990
• Mol file: 2359-60-6.mol

Synonyms:1-(p-Aminophenyl)piperidine;4-(1-Piperidinyl)aniline;4-Piperidin-1-yl-phenylamine;

Chemical Property of 4-Piperidinoaniline

Chemical Property:

• Vapor Pressure: 6.32E-05mmHg at 25°C
• Melting Point: 26-29 °C(lit.)
• Refractive Index: n20/D 1.5937(lit.)
• Boiling Point: 345.1 °C at 760 mmHg
• PKA: 7.79±0.10(Predicted)
• Flash Point: 140.3 °C
• PSA: 29.26000
• Density: 1.074 g/cm³
• LogP: 2.90530
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Piperidinoaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36/37-20/21/22
• Safety Statements: 26-36-36/37/39-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Reactant for synthesis of:Amino acid arylamidesSelective interleukin-2 inducible T-cell inhibitorsAntimalarial drugsAglycoristocetin derivatives for anti-influenza virus activityIRAK-4 inhibitors9-Aminoacridines with antiprion activity

Technology Process of 4-Piperidinoaniline

There total 18 articles about 4-Piperidinoaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-nitrophenyl)piperidine (6574-15-8) → 4-(1-piperidino)aniline (2359-60-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; at 20 ℃; for 3h;

Reference yield: 100.0%

→ 4-(1-piperidino)aniline (2359-60-6)

Guidance literature:

Reference yield: 76.0%

piperidine (110-89-4) + 4-chloro-aniline (106-47-8) → 4-(1-piperidino)aniline (2359-60-6)

Guidance literature:

With water; sodium t-butanolate; In toluene; at 105 ℃; for 9h; Schlenk technique;

DOI:10.1016/j.tetlet.2015.12.020

upstream raw materials:

N-phenyl piperidine

1-(4-nitrophenyl)piperidine

N-(p-nitrophenyl)pyridinium chloride

1,5-dibromo-pentane

Downstream raw materials:

methyl-[1,4]benzoquinone-4-(4-piperidino-phenylimine)

N-(4-ethoxy-phenyl)-N'-(4-piperidino-phenyl)-thiourea

2-Chloronaphthalene-1,4,5,8-tetracarboxylic acid N,N'-bis(4-piperidinophenyl)diimide

2,6-Dichloronaphthalene-1,4,5,8-tetracarboxylic acid N,N'-bis(4-piperidinophenyl)diimide

Refernces

• 1、 Watanabe et al.. "-". . p. 2302,2303. Retrieved 1976.
• 2、 Yang, Huali,Wang, Xiaobing,Wang, Cheng,Yin, Fucheng,Qu, Lailiang,Shi, Cunjian,Zhao, Jinhua,Li, Shang,Ji, Limei,Peng, Wan,Luo, Heng,Cheng, Maosheng,Kong, Lingyi. "Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer". . . Retrieved 2020/12/15.
• 3、 Barker, David,Langley, Ries J.,Leung, Euphemia,Leung, Ivanhoe K. H.,Paulin, Emily K.,Pilkington, Lisa I.,Rees, Shaun W. P.,Reynisson, Jóhannes,Sparrow, Kevin,Xu, Chris Sun,van Rensburg, Michelle. "Development, synthesis and biological investigation of a novel class of potent PC-PLC inhibitors". . . Retrieved 2020/02/27.