4-Fluorobutanenitrile

Base Information

• Chemical Name: 4-Fluorobutanenitrile
• CAS No.: 407-83-0
• Molecular Formula: C4H6FN
• Molecular Weight: 87.11
• Mol file: 407-83-0.mol

Synonyms:BUTYRONITRILE,4-FLUORO;4-fluorobutyronitrile;TL 1126;4-Fluorbutannitril;Butanenitrile, 4-fluoro-;4-Fluor-butyronitril;

Chemical Property of 4-Fluorobutanenitrile

Chemical Property:

• Vapor Pressure: 5.16mmHg at 25°C
• Boiling Point: 144.1°Cat760mmHg
• Flash Point: 43.2°C
• PSA: 23.79000
• Density: 0.932g/cm³
• LogP: 1.25968

Purity/Quality:

99% ^*data from raw suppliers

4-Fluorobutanenitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluorobutanenitrile

There total 5 articles about 4-Fluorobutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-((cyclobutylideneamino)oxy)-2-methylpropanoic acid → 4-fluorobutanenitrile (407-83-0)

Guidance literature:

With potassium carbonate; Selectfluor; 9-(2-mesityl)-10-methylacridinium perchlorate; In [D₃]acetonitrile; water-d2; at 20 ℃; for 0.25h; Irradiation; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.201710790

Reference yield:

1-Bromo-3-fluoropropane (352-91-0) + sodium cyanide (143-33-9,25596-52-5) → 4-fluorobutanenitrile (407-83-0)

Guidance literature:

With ethylene glycol;

DOI:10.1021/ja01595a058

Reference yield:

1-Bromo-3-fluoropropane (352-91-0) → 4-fluorobutyraldehyde (462-74-8) + 4-fluorobutanenitrile (407-83-0)

Guidance literature:

upstream raw materials:

1-Bromo-3-fluoropropane

sodium cyanide

4-azidobutanenitrile

Refernces

• 1、 Dauncey, Elizabeth M.,Morcillo, Sara P.,Douglas, James J.,Sheikh, Nadeem S.,Leonori, Daniele. "Photoinduced Remote Functionalisations by Iminyl Radical Promoted C?C and C?H Bond Cleavage Cascades". supporting information. p. 744 - 748. Retrieved 2017/12/13.