Technology Process of Carbamic acid,
[3-amino-2-(hydroxymethyl)-2-[[(4-methoxyphenyl)diphenylmethoxy]meth
yl]propyl]-, 1,1-dimethylethyl ester
There total 15 articles about Carbamic acid,
[3-amino-2-(hydroxymethyl)-2-[[(4-methoxyphenyl)diphenylmethoxy]meth
yl]propyl]-, 1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / pyridine / 20 °C
2: 84 percent / NaN3; LiCl / dimethylformamide; pyridine / 5 h / Heating
3: 45 percent / NaBH4; 1,3-propanedithiol; Et3N / propan-2-ol / 24 h / 20 °C
4: 99 percent / aq. NaOH / acetonitrile
5: tetrahydrofuran / 20 °C
6: 5.71 g / aq. NH3 / tetrahydrofuran / 3 h / Heating
With
pyridine; 1.3-propanedithiol; ammonium hydroxide; sodium hydroxide; sodium tetrahydroborate; sodium azide; triethylamine; lithium chloride;
In
tetrahydrofuran; pyridine; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
5: Staudinger reaction;
DOI:10.1021/jo026053b
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 55 percent / pyridine / 3 h / 20 °C
2: 98 percent / triphenylphosphane; diethyl azodicarboxylate / tetrahydrofuran / 20 °C
3: 81 percent / hydrazine monohydrate / ethanol / 20 °C
4: 88 percent / 2M NaOH / acetonitrile; H2O / 20 °C
5: 72 percent / tert-butyl hydroperoxide / palladium acetate / benzene / 408 h / 20 °C
6: 96 percent / DEAD; triphenylphosphane / tetrahydrofuran / 48 h / 20 °C
7: 61 percent / sodium methoxide / methanol / 2 h / 20 °C
8: 86 percent / hydrazine monohydrate / ethanol / 20 °C
With
tert.-butylhydroperoxide; sodium hydroxide; sodium methylate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate;
palladium diacetate;
In
tetrahydrofuran; pyridine; methanol; ethanol; water; acetonitrile; benzene;
2: Mitsunobu reaction;
DOI:10.1002/1099-0690(200109)2001:18<3467::AID-EJOC3467>3.0.CO;2-A