Benzeneacetic acid, 2-(phenylamino)-, methyl ester

Base Information

• Chemical Name: Benzeneacetic acid, 2-(phenylamino)-, methyl ester
• CAS No.: 39507-06-7
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• Mol file: 39507-06-7.mol

Synonyms:

Chemical Property of Benzeneacetic acid, 2-(phenylamino)-, methyl ester

Chemical Property:

• PSA: 38.33000
• LogP: 3.21870

Purity/Quality:

99%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, 2-(phenylamino)-, methyl ester

There total 6 articles about Benzeneacetic acid, 2-(phenylamino)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl iodide (74-88-4) + sodium; (2-phenylamino-phenyl)-acetate → (2-phenylamino-phenyl)-acetic acid methyl ester (39507-06-7)

Guidance literature:

In N,N-dimethyl-formamide; at 24 ℃; for 4h;

DOI:10.1016/j.tetlet.2004.05.014

Reference yield:

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + methyl iodide (74-88-4) → (2-phenylamino-phenyl)-acetic acid methyl ester (39507-06-7)

Guidance literature:

1-phenyl-1,3-dihydro-indol-2-one; With sodium hydroxide; In ethanol; water; at 50 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1021/op049760a

Reference yield:

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) → (2-phenylamino-phenyl)-acetic acid methyl ester (39507-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / aq. NaOH / 6 h / 100 °C

With sodium hydroxide;

DOI:10.1016/j.tetlet.2004.05.014

upstream raw materials:

dimethyl sulfate

methyl iodide

1-phenyl-1,3-dihydro-indol-2-one

[2-(methoxycarbonyl-phenyl-amino)-phenyl]-acetic acid methyl ester

Downstream raw materials:

{2-[Phenyl-(2,2,2-trifluoro-acetyl)-amino]-phenyl}-acetic acid

[2-(benzyl-phenyl-amino)-phenyl]-acetic acid

(2-phenylamino-phenyl)-acetic acid benzyl ester

[2-(acetyl-phenyl-amino)-phenyl]-acetic acid

Refernces

• 1、 Kaufmann, Daniel,Fünfschilling, Peter C.,Beutler, Ulrich,Hoehn, Pascale,Lohse, Olivier,Zaugg, Werner. "A new synthesis of oxcarbazepine using a Friedel-Crafts cyclization strategy". . p. 5275 - 5278. Retrieved 2007/10/03.