N-Piperidin-4-ylbenzamide

Base Information

• Chemical Name: N-Piperidin-4-ylbenzamide
• CAS No.: 33953-37-6
• Molecular Formula: C12H16 N2 O
• Molecular Weight: 204.272
• Hs Code.: 2933399090
• European Community (EC) Number: 251-759-1
• DSSTox Substance ID: DTXSID70955533
• Nikkaji Number: J287.835F
• Wikidata: Q72501027
• Mol file: 33953-37-6.mol

Synonyms:33953-37-6;n-(piperidin-4-yl)benzamide;N-Piperidin-4-ylbenzamide;N-Piperidin-4-yl-benzamide;N-(4-Piperidyl)benzamide;Benzamide, N-4-piperidinyl-;4-Benzamidopiperidine;N-4-Piperidylbenzamide;4-Benzimido piperidine;EINECS 251-759-1;N-(4-Piperidinyl)benzamide;N-4-piperidinylbenzamide;4 -benzamidopiperidine;4-ben-zamidopiperidine;4-benzamido-piperidine;4-benzoylaminopiperidine;Oprea1_555073;SCHEMBL594567;N-(4-Piperidinyl)benzamide #;DTXSID70955533;STL183881;AKOS000200755;FS-1814;n-piperidin-4-yl-benzamide, AldrichCPR;AC-13181;N-(Piperidin-4-yl)benzenecarboximidic acid;B3025;CS-0108681;FT-0639139;EN300-24697;D76846;J-523761;Z199507048

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Chemical Property of N-Piperidin-4-ylbenzamide

Chemical Property:

• Vapor Pressure: 5.26E-06mmHg at 25°C
• Melting Point: 137 °C
• Refractive Index: 1.558
• Boiling Point: 412.4ºC at 760 mmHg
• PKA: 14.35±0.20(Predicted)
• Flash Point: 174.8 ºC
• PSA: 41.13000
• Density: 1.11 g/cm³
• LogP: 1.88810
• Storage Temp.: 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 204.126263138
• Heavy Atom Count: 15
• Complexity: 206

Purity/Quality:

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1NC(=O)C2=CC=CC=C2
• Uses: N-(Piperidin-4-yl)benzamide is used in preparation of [(azaheterocyclyl)thiazolyl] heteroaryl ketones as vanin-1 inhibitors.

Technology Process of N-Piperidin-4-ylbenzamide

There total 10 articles about N-Piperidin-4-ylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-benzyl-4-benzamidopiperidine (971-34-6) → N-(piperidin-4-yl)benzamide (33953-37-6)

Guidance literature:

With palladium on activated charcoal; ammonium formate; In methanol;

DOI:10.1016/S0960-894X(03)00437-2

Reference yield:

tert-butyl 4-benzamidopiperidine-1-carboxylate (955050-02-9) → N-(piperidin-4-yl)benzamide (33953-37-6)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 2h;

DOI:10.1021/jm100697g

Reference yield:

N-benzyl-2-piperidinone (4783-65-7) → N-(piperidin-4-yl)benzamide (33953-37-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; hydroxylamine hydrochloride / diethyl ether; water

2: potassium carbonate / dichloromethane; water

3: palladium / ethanol

With sodium hydroxide; hydroxylamine hydrochloride; potassium carbonate; palladium; In diethyl ether; ethanol; dichloromethane; water;

upstream raw materials:

1-benzyl-4-benzamidopiperidine

4-amino-1-benzylpiperidine

benzoyl chloride

tert-butyl 4-benzamidopiperidine-1-carboxylate

Downstream raw materials:

1-Acetyl-4-benzamidopiperidin

N-[1-(4-chloro-phenethyl)-piperidin-4-yl]-benzamide

N-[1-(4-methoxy-phenethyl)-piperidin-4-yl]-benzamide

1-[3-(1-Naphthoxy)-2-hydroxyprop-1-yl]-4-benzamidopiperidine

Refernces

• 1、 Verma, Sanjeev K.,Ghorpade, Ramarao,Pratap, Ajay,Kaushik. "CDI-mediated monoacylation of symmetrical diamines and selective acylation of primary amines of unsymmetrical diamines". experimental part. p. 326 - 329. Retrieved 2012/04/10.
• 2、 Manetti, Dina,Martini, Elisabetta,Ghelardini, Carla,Dei, Silvia,Galeotti, Nicoletta,Guandalini, Luca,Romanelli, Maria Novella,Scapecchi, Serena,Teodori, Elisabetta,Bartolini, Alessandro,Gualtieri, Fulvio. "4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs". . p. 2303 - 2306. Retrieved 2007/10/03.