CYCLOPROPYL 2-METHYLPHENYL KETONE

Base Information

• Chemical Name: CYCLOPROPYL 2-METHYLPHENYL KETONE
• CAS No.: 39615-34-4
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• Hs Code.: 2914399090
• Mol file: 39615-34-4.mol

Synonyms:Cyclopropyl-o-tolyl-keton;Methanone,cyclopropyl(2-methylphenyl);cyclopropyl-o-tolyl ketone;cyclopropyl(2-methylphenyl)methanone;CYCLOPROPYL 2-METHYLPHENYL KETONE;cyclopropyl-(o-tolyl)methanone;

Chemical Property of CYCLOPROPYL 2-METHYLPHENYL KETONE

Chemical Property:

• Vapor Pressure: 0.017mmHg at 25°C
• Boiling Point: 254.617oC at 760 mmHg
• Flash Point: 102.571oC
• PSA: 17.07000
• Density: 1.093g/cm3
• LogP: 2.58770
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Cyclopropyl2-methylphenylketone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOPROPYL 2-METHYLPHENYL KETONE

There total 15 articles about CYCLOPROPYL 2-METHYLPHENYL KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

C17H26OSi → (2-methyl)phenyl cyclopropyl ketone (39615-34-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; para-xylene; at 20 - 60 ℃; for 24h; Time; Inert atmosphere;

DOI:10.1002/chem.201405712

Reference yield: 7.0%

benzocyclobutenone (3469-06-5) + triphenylphosphonium cyclopropylide (14633-95-5,7666-30-0) → (2-methyl)phenyl cyclopropyl ketone (39615-34-4)

Guidance literature:

With Tris(3,6-dioxaheptyl)amine; for 144h;

DOI:10.1016/j.tet.2003.08.045

Reference yield:

benzocyclobutenone (3469-06-5) → (2-methyl)phenyl cyclopropyl ketone (39615-34-4)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 1 h / -78 °C

2: 1H-imidazole; dmap / N,N-dimethyl-formamide / 48 h / 20 °C

3: tetrabutyl ammonium fluoride / para-xylene; tetrahydrofuran / 24 h / 20 - 60 °C / Inert atmosphere

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; In tetrahydrofuran; para-xylene; N,N-dimethyl-formamide;

DOI:10.1002/chem.201405712

upstream raw materials:

ortho-tolylmagnesium bromide

cyclopropropanecarbonitrile

bromobenzene

Cyclopropyl methyl ketone

Downstream raw materials:

C₁₇H₂₅BO₃

1-Cyclopropyl-2-phenyl-1-o-tolyl-ethanol

C₁₁H₁₄O

1,1-bis(2-methylphenyl)-4-bromo-1-butene

Refernces

• 1、 Bonetti, Vittorio,He, Tao,Klare, Hendrik F. T.,Oestreich, Martin,Wang, Guoqiang. "Silylium-Ion-Promoted (5+1) Cycloaddition of Aryl-Substituted Vinylcyclopropanes and Hydrosilanes Involving Aryl Migration". supporting information. p. 12186 - 12191. Retrieved 2020/05/22.
• 2、 Sun, Yan,Huang, Xin,Li, Xiaojin,Luo, Fan,Zhang, Lei,Chen, Mengyuan,Zheng, Shiya,Peng, Bo. "Mild Ring Contractions of Cyclobutanols to Cyclopropyl Ketones via Hypervalent Iodine Oxidation". . p. 1082 - 1087. Retrieved 2018/01/27.