N-(3-chlorophenyl)-2-phenylacetamide

Base Information

• Chemical Name: N-(3-chlorophenyl)-2-phenylacetamide
• CAS No.: 18109-43-8
• Molecular Formula: C14H12 Cl N O
• Molecular Weight: 245.708
• Hs Code.: 2924299090
• NSC Number: 205449
• DSSTox Substance ID: DTXSID40308613
• Nikkaji Number: J418.105K
• Wikidata: Q82056574
• Mol file: 18109-43-8.mol

Synonyms:N-(3-chlorophenyl)-2-phenylacetamide;18109-43-8;Acetamide, N-(3-chlorophenyl)-2-phenyl-;HMS1579A03;NSC205449;Cambridge id 5270350;CBDivE_012908;SCHEMBL11531211;DTXSID40308613;STK412531;AKOS002982884;NSC-205449;AB00078446-01;AO-548/41018825;H1Y

Chemical Property of N-(3-chlorophenyl)-2-phenylacetamide

Chemical Property:

• Vapor Pressure: 4.19E-08mmHg at 25°C
• Boiling Point: 444.7°Cat760mmHg
• Flash Point: 222.7°C
• PSA: 29.10000
• Density: 1.258g/cm³
• LogP: 3.59420
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 245.0607417
• Heavy Atom Count: 17
• Complexity: 251

Purity/Quality:

98%,99%, ^*data from raw suppliers

3'-CHLORO-2-PHENYLACETANILIDE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(=O)NC2=CC(=CC=C2)Cl

Technology Process of N-(3-chlorophenyl)-2-phenylacetamide

There total 10 articles about N-(3-chlorophenyl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butyl N-(3-chlorophenyl)-N-(phenylethynyl)carbamate → N-(3-chlorophenyl)-2-phenylacetamide (18109-43-8)

Guidance literature:

With water; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2016.03.052

Reference yield: 72.0%

phenylacetic acid (103-82-2) + 3-chloro-aniline (108-42-9) → N-(3-chlorophenyl)-2-phenylacetamide (18109-43-8)

Guidance literature:

With n-butylstannoic acid; In toluene; at 110 ℃; for 15h; Dean-Stark;

DOI:10.1016/j.tetlet.2018.11.036

Reference yield: 64.0%

carbon monoxide (201230-82-2) + 3-chloro-aniline (108-42-9) + toluene (108-88-3,15644-74-3,16713-13-6) → N-(3-chlorophenyl)-2-phenylacetamide (18109-43-8)

Guidance literature:

With di-tert-butyl peroxide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium dichloride; at 125 ℃; for 24h; under 38002.6 Torr; Autoclave;

DOI:10.1039/c3cc47015f

upstream raw materials:

3-chloro-aniline

phenylacetyl chloride

carbon monoxide

toluene

Downstream raw materials:

3-chloro-1-(3-chlorophenyl)-4-phenyl-1H-pyrrole-2,5-dione

N-(3-chlorophenyl)-2-oxo-2-phenylacetamide

Refernces

• 1、 Bera, Jitendra K.,Pandey, Pragati. "Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex". supporting information. p. 9204 - 9207. Retrieved 2021/09/20.
• 2、 Han, Zhang,Chaowei, Dai,Lice, Liu,Hongfei, Ma,Hongzhong, Bu,Yufeng, Li. "Nickel (II)-Catalyzed efficient aminocarbonylation of unreactive alkanes with formanilides—Exploiting the deformylation behavior of imides". . p. 3712 - 3718. Retrieved 2018/05/29.