Pyridine, 2,6-dimethyl-4-(3-nitrophenyl)-, 1-oxide

Base Information

• Chemical Name: Pyridine, 2,6-dimethyl-4-(3-nitrophenyl)-, 1-oxide
• CAS No.: 40034-61-5
• Molecular Formula: C13H12N2O3
• Molecular Weight: 244.25
• Mol file: 40034-61-5.mol

Synonyms:

Chemical Property of Pyridine, 2,6-dimethyl-4-(3-nitrophenyl)-, 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyridine, 2,6-dimethyl-4-(3-nitrophenyl)-, 1-oxide

There total 7 articles about Pyridine, 2,6-dimethyl-4-(3-nitrophenyl)-, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,6-dimethyl-4-(3-nitrophenyl)pyridine (40034-60-4) → 2,6-Dimethyl-4-(3-nitrophenyl)pyridine N(py)-oxide (40034-61-5)

Guidance literature:

With dihydrogen peroxide; In acetic acid; for 3h; Heating;

DOI:10.1002/jhet.5570210654

Reference yield:

m-nifedipine (21881-77-6) → 2,6-Dimethyl-4-(3-nitrophenyl)pyridine N(py)-oxide (40034-61-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / 4N aq. HNO₃ / 1 h / Heating

2: 82 percent / NaOH / aq. ethanol / 2 h / Heating

3: 99 percent / 1.5 h / Heating; heating in Dowterm

4: 100 percent / aq. H₂O₂, 30percent / acetic acid / 3 h / Heating

With sodium hydroxide; dihydrogen peroxide; nitric acid; In ethanol; acetic acid;

DOI:10.1002/jhet.5570210654

Reference yield:

3-nitro-benzaldehyde (99-61-6) → 2,6-Dimethyl-4-(3-nitrophenyl)pyridine N(py)-oxide (40034-61-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / conc. aq. ammonium hydroxide / methanol / 4 h / Heating

2: 96 percent / 4N aq. HNO₃ / 1 h / Heating

3: 82 percent / NaOH / aq. ethanol / 2 h / Heating

4: 99 percent / 1.5 h / Heating; heating in Dowterm

5: 100 percent / aq. H₂O₂, 30percent / acetic acid / 3 h / Heating

With ammonium hydroxide; sodium hydroxide; dihydrogen peroxide; nitric acid; In methanol; ethanol; acetic acid;

DOI:10.1002/jhet.5570210654

upstream raw materials:

2,6-dimethyl-4-(3-nitrophenyl)pyridine

2,6-dimethyl-4-phenylpyridine N-oxide

m-nifedipine

3-nitro-benzaldehyde

Downstream raw materials:

6-Methyl-4-(3-nitrophenyl)-2-pyridinemethanol

6-Methyl-4-(3-nitrophenyl)-2-pyridinecarboxaldehyde

Refernces

• 1、 Prostakov, N. S.,Soldatenkov, A. T.,Krapivko, A. P.,Fomichev, A. A.,Mikaya, A. I.,Ustenko, A. A.. "NITRATION OF ALKYL-SUBSTITUTED 4-ARYL(BENZOYL)PYRIDINES". . p. 958 - 963. Retrieved 2007/10/02.