7-METHOXYFLAVONOL

Base Information

• Chemical Name: 7-METHOXYFLAVONOL
• CAS No.: 7478-60-6
• Molecular Formula: C16H12 O4
• Molecular Weight: 268.269
• Hs Code.: 2914509090
• Mol file: 7478-60-6.mol

Synonyms:Flavone,3-hydroxy-7-methoxy- (7CI,8CI); 3-Hydroxy-7-methoxyflavone; 7-Methoxyflavonol;NSC 401510

Chemical Property of 7-METHOXYFLAVONOL

Chemical Property:

• Vapor Pressure: 9.3E-09mmHg at 25°C
• Melting Point: 177-178°C
• Boiling Point: 446.6°C at 760 mmHg
• Flash Point: 169.4°C
• PSA: 59.67000
• Density: 1.353g/cm³
• LogP: 3.17420

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Methoxyflavonol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 7-Methoxyflavonol (cas# 7478-60-6) is a flavenoid which, as a class of compounds, have broad pharmacological activity, including binding to biomolecules such as enzymes, hormone carriers, and DNA, chelating transition metal ions, catalyzing electron transport, and scavenging free radicals.

Technology Process of 7-METHOXYFLAVONOL

There total 44 articles about 7-METHOXYFLAVONOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1a,7a-Dihydro-4-methoxy-1a-phenyl-7H-oxireno<1>benzopyran-7-one (136764-58-4) → 7-methoxyflavonol (7478-60-6)

Guidance literature:

In chloroform-d1; for 24h; Ambient temperature;

DOI:10.1021/jo00026a020

Reference yield: 88.0%

7-methoxy-2-phenyl-3-nitro-2H-chromene (105849-85-2) → 7-methoxyflavonol (7478-60-6)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In methanol; for 0.5h;

Reference yield: 72.0%

1-(2-hydroxy-4-methoxyphenyl)ethanone (552-41-0) + benzaldehyde (100-52-7) → 7-methoxyflavonol (7478-60-6)

Guidance literature:

With pyrrolidine; oxygen; In water; at 50 ℃; under 760.051 Torr;

DOI:10.1021/acs.joc.0c01869

upstream raw materials:

1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropane-1,3-dione

3,7-dihydroxyflavone

dimethyl sulfate

2,3-dihydro-3-hydroxy-7-methoxyflavone

Downstream raw materials:

3-Hydroxy-7-methoxyflavone 3-glucuronide

3-(allyloxy)-7-methoxy-2-phenyl-4H-chromen-4-one

Co(C₂H₄(NCHC₆H₄O)2)(C₉H₃O₃(OCH₃)C₆H₅)

4-methoxysalicylic acid

Refernces

• 1、 Zheng, Yuanyuan,Pu, Wenchen,Li, Jiao,Shen, Xianyan,Zhou, Qiang,Fan, Xin,Yang, Sheng-Yong,Yu, Yamei,Chen, Qiang,Wang, Chun,Wu, Xin,Peng, Yong. "Discovery of a Prenylated Flavonol Derivative as a Pin1 Inhibitor to Suppress Hepatocellular Carcinoma by Modulating MicroRNA Biogenesis". . p. 130 - 134. Retrieved 2018/11/30.
• 2、 Shen, Xianyan,Zhou, Qiang,Xiong, Wei,Pu, Wenchen,Zhang, Wei,Zhang, Guolin,Wang, Chun. "Synthesis of 5-subsituted flavonols via the Algar-Flynn-Oyamada (AFO) reaction: The mechanistic implication". . p. 4822 - 4829. Retrieved 2017/07/17.