1,4,8,12-Tetraazacyclopentadecane

Base Information

• Chemical Name: 1,4,8,12-Tetraazacyclopentadecane
• CAS No.: 15439-16-4
• Molecular Formula: C11H26N4
• Molecular Weight: 214.354
• Hs Code.: 29339980
• Mol file: 15439-16-4.mol

Synonyms:cyclal;

Chemical Property of 1,4,8,12-Tetraazacyclopentadecane

Chemical Property:

• Appearance/Colour: White to light yellow needle-like cryst. powder
• Vapor Pressure: 9.95E-05mmHg at 25°C
• Melting Point: 96-102 °C(lit.)
• Refractive Index: 1.4260 (estimate)
• Boiling Point: 338.245 °C at 760 mmHg
• Flash Point: 163.737 °C
• PSA: 48.12000
• Density: 0.857 g/cm³
• LogP: 0.84390
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,4,8,12-Tetraazacyclopentadecane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 1,4,8,12-Tetraazacyclopentadecane

There total 9 articles about 1,4,8,12-Tetraazacyclopentadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1,4,8,12-tetrakis(p-tolylsulphonyl)-1,4,8,12-tetra-azacyclopentadecane (69038-12-6) → 1,4,8,12-Tetraazacyclopentadecan (15439-16-4)

Guidance literature:

With sulfuric acid; at 100 - 105 ℃; Heating; 50-70 h;

DOI:10.1007/BF00472559

Reference yield:

[(3-pyridylmethyl)Cr(1,4,8,12-tetraazacyclopentadecane)(H2O)](2+) (99708-69-7) → 1,4,8,12-Tetraazacyclopentadecan (15439-16-4) + 3-Methylpyridine (108-99-6) + chromium(III) hexahydrate cation (14873-01-9)

Guidance literature:

In perchloric acid; (N2); decompn. of Cr complex in 1 M HClO4 depending on temp. under anaerobic conditions; not isolated, monitored by UV; Kinetics;

Reference yield:

[C5H4NCH2Cr(C11H26N4)(H2O)](2+) (99708-68-6) → α-picoline (109-06-8) + 1,4,8,12-Tetraazacyclopentadecan (15439-16-4) + chromium(III) hexahydrate cation (14873-01-9)

Guidance literature:

In perchloric acid; (N2); decompn. of Cr complex in 1 M HClO4 depending on temp. under anaerobic conditions; not isolated, monitored by UV; Kinetics;

upstream raw materials:

1,4,8,12-tetrakis(p-tolylsulphonyl)-1,4,8,12-tetra-azacyclopentadecane

1,4,8,12-Tetrakis-trifluoromethanesulfonyl-1,4,8,12-tetraaza-cyclopentadecane

N,N'-bis(3-aminopropyl)-1,2-diamine

N,N',N'',N'''-tetratosyl-1,10-diamino-4,7-diazadecane

Downstream raw materials:

1,4,8,12-tetrakis-(2-pyridylmethyl)-1,4,8,12-tetraazacyclopentadecane

Benzyl-(5-{4,8,12-tris-[5-(benzyl-tert-butoxycarbonyl-amino)-pentyl]-1,4,8,12-tetraaza-cyclopentadec-1-yl}-pentyl)-carbamic acid tert-butyl ester

dichloro(1,4,8,12-tetraazacyclopentadecane)bis(triphenylphosphine)ruthenium(II)

[([15]aneN₄)Fe(II)(SPh)]BF₄

Refernces

• 1、 Panetta,Yaouanc,Handel. "Triflamides for protection and cyclization of tetraamines to tetraazamacrocycles". . p. 5505 - 5508. Retrieved 2007/10/02.
• 2、 Lukyanenko, Nikolai G.,Basok, Stepan S.,Filonova, Lyubov K.. "MACROHETEROCYCLES. PART 44. FACILE SYNTHESIS OF AZACROWN ETHERS AND CRYPTANDS IN A TWO-PHASE SYSTEM". . p. 3141 - 3148. Retrieved 2007/10/02.