Benzene, 1-fluoro-3-(phenylsulfonyl)-

Base Information

• Chemical Name: Benzene, 1-fluoro-3-(phenylsulfonyl)-
• CAS No.: 40154-94-7
• Molecular Formula: C12H9FO2S
• Molecular Weight: 236.267
• Mol file: 40154-94-7.mol

Synonyms:

Chemical Property of Benzene, 1-fluoro-3-(phenylsulfonyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 1-fluoro-3-(phenylsulfonyl)-

There total 8 articles about Benzene, 1-fluoro-3-(phenylsulfonyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-fluorobenzene-1-sulfonyl chloride (701-27-9) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → m-fluorophenyl phenyl sulfone (40154-94-7)

Guidance literature:

With aluminum (III) chloride; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03866

Reference yield: 81.0%

1-fluoro-3-phenylsulfanyl-benzene (40154-91-4) → m-fluorophenyl phenyl sulfone (40154-94-7)

Guidance literature:

With palladium; dihydrogen peroxide; In methanol; at 100 ℃; for 15h; chemoselective reaction; Green chemistry;

DOI:10.1039/c8ob03209b

Reference yield: 75.0%

1-Fluoro-3-iodobenzene (1121-86-4) + sodium benzenesulfonate (873-55-2) → m-fluorophenyl phenyl sulfone (40154-94-7)

Guidance literature:

With [2,2]bipyridinyl; nickel(II) chloride hexahydrate; tributyl-amine; tris(2,2′-bipyridyl)dichlororuthenium(II) hexahydrate; In dimethyl sulfoxide; at 25 ℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation;

DOI:10.1021/acs.orglett.7b03896

upstream raw materials:

1-fluoro-3-phenylsulfanyl-benzene

1-Fluoro-3-iodobenzene

potassium thiophenolate

3-fluorophenylboronic acid

Downstream raw materials:

(3-benzenesulfonyl-phenyl)-hydrazine

1-Benzenesulfonyl-3-fluoro-benzene; compound with N-(2-dimethylamino-ethyl)-N,N',N'-trimethyl-ethane-1,2-diamine

Refernces

• 1、 Li, Xing,Du, Jia,Zhang, Yongli,Chang, Honghong,Gao, Wenchao,Wei, Wenlong. "Synthesis and nano-Pd catalyzed chemoselective oxidation of symmetrical and unsymmetrical sulfides". . p. 3048 - 3055. Retrieved 2019/03/21.
• 2、 Wu, Xiang-Mei,Wang, Yan. "A mild and base-free synthesis of unsymmetrical diaryl sulfones from arylboronic acids and arylsulfonyl hydrazides". supporting information. p. 1163 - 1167. Retrieved 2014/05/20.