2'-METHOXY-P-TOLUENESULFONANILIDE

Base Information

• Chemical Name: 2'-METHOXY-P-TOLUENESULFONANILIDE
• CAS No.: 6295-94-9
• Molecular Formula: C14H15NO3S
• Molecular Weight: 277.344
• Mol file: 6295-94-9.mol

Synonyms:toluene-4-sulfonic acid o-anisidide;N-(2-methoxyphenyl)-p-toluenesulfonamide;Benzenesulfonamide, N-(2-methoxyphenyl)-4-methyl-;Toluol-4-sulfonsaeure-o-anisidid;N-(2-methoxyphenyl)-4-methyl-benzenesulfonamide;N-tosyl-2-anisidine;

Chemical Property of 2'-METHOXY-P-TOLUENESULFONANILIDE

Chemical Property:

• Vapor Pressure: 2.16E-07mmHg at 25°C
• Boiling Point: 423.9°Cat760mmHg
• Flash Point: 210.1°C
• PSA: 63.78000
• Density: 1.267g/cm³
• LogP: 3.95820

Purity/Quality:

99% ^*data from raw suppliers

N-(2-METHOXY-PHENYL)-4-METHYL-BENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-METHOXY-P-TOLUENESULFONANILIDE

There total 10 articles about 2'-METHOXY-P-TOLUENESULFONANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-methoxy-phenylamine (90-04-0) + p-toluenesulfonyl chloride (98-59-9) → N-tosyl-2-anisidine (6295-94-9)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1002/anie.201806659

Reference yield: 94.0%

2-methoxy-phenylamine (90-04-0) + toluene-4-sulfonic acid hydrazide (1576-35-8) → N-tosyl-2-anisidine (6295-94-9)

Guidance literature:

toluene-4-sulfonic acid hydrazide; With N-chloro-succinimide; In acetonitrile; at 20 ℃; for 2h;

2-methoxy-phenylamine; With triethylamine; at 20 ℃; for 2h;

DOI:10.3390/molecules26185551

Reference yield: 93.0%

4-toluenesulfonyl azide (941-55-9) + 2-Methoxyphenylboronic acid (5720-06-9) → N-tosyl-2-anisidine (6295-94-9)

Guidance literature:

With copper(l) chloride; In methanol; at 20 ℃; for 1h;

DOI:10.1021/ol403717

upstream raw materials:

2-methoxy-phenylamine

p-toluenesulfonyl chloride

ethyl β-(N-tosyl-o-anisidino)propionate

4-iodoanisol

Refernces

• 1、 Cho, Myoung Ki,Je, Jong Tae,Juvekar, Vinayak,Kang, Hyuk,Kim, Hwan Myung,Lee, Dong Joon,Lee, Hyo Won,Song, Ju Man. "A red-emissive two-photon fluorescent probe for mitochondrial sodium ions in live tissue". supporting information. p. 8929 - 8932. Retrieved 2021/09/10.
• 2、 Xu, Zi-Yue,Luo, Yi,Zhang, Dan-Wei,Wang, Hui,Sun, Xing-Wen,Li, Zhan-Ting. "Iridium complex-linked porous organic polymers for recyclable, broad-scope photocatalysis of organic transformations". supporting information. p. 136 - 143. Retrieved 2020/01/21.