2-(4-(Benzyloxy)phenyl)acetaldehyde

Base Information

• Chemical Name: 2-(4-(Benzyloxy)phenyl)acetaldehyde
• CAS No.: 40167-10-0
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID90465104
• Nikkaji Number: J1.754.416K
• Wikidata: Q82290800
• Mol file: 40167-10-0.mol

Synonyms:2-(4-(Benzyloxy)phenyl)acetaldehyde;40167-10-0;4-(Phenylmethoxy)-benzeneacetaldehyde;4-Benzyloxyphenylacetaldehyde;2-(4-phenylmethoxyphenyl)acetaldehyde;(4-Benzyloxyphenyl)acetaldehyde;2-[4-(benzyloxy)phenyl]acetaldehyde;SCHEMBL42303;p-benzyloxy-phenyl-acetaldehyde;DTXSID90465104;(4-benzyloxy-phenyl)-acetaldehyde;FVIRBJOGMPKDHO-UHFFFAOYSA-N;MFCD11553534;AKOS014198243;CS-0380541;FT-0673792;A918936;A1-16530

Chemical Property of 2-(4-(Benzyloxy)phenyl)acetaldehyde

Chemical Property:

• Boiling Point: 373.1±22.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.107±0.06 g/cm3(Predicted)
• LogP: 3.00700
• Storage Temp.: 2-8°C
• Solubility.: CDCl3, CD3OD
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 226.099379685
• Heavy Atom Count: 17
• Complexity: 213

Purity/Quality:

98% ^*data from raw suppliers

4-(Phenylmethoxy)-benzeneacetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)CC=O
• Uses: 4-(Phenylmethoxy)-benzeneacetaldehyde (cas# 40167-10-0 ) is a compound useful in organic synthesis.

Technology Process of 2-(4-(Benzyloxy)phenyl)acetaldehyde

There total 15 articles about 2-(4-(Benzyloxy)phenyl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(4-benzyloxyphenyl)ethanol (61439-59-6) → 2-[4-(benzyloxy)phenyl]acetaldehyde (40167-10-0)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; for 1.33333h;

DOI:10.1016/j.bmcl.2007.04.017

Reference yield: 90.0%

1-(benzyloxy)-4-(2-methoxyethenyl)benzene (82099-81-8) → 2-[4-(benzyloxy)phenyl]acetaldehyde (40167-10-0)

Guidance literature:

With oxalyl dichloride; In ethanol; chloroform; water; at 20 ℃; for 1h;

DOI:10.3987/COM-14-13157

Reference yield:

C29H25NO4 → p-benzyloxybenzaldehyde (4397-53-9) + 2-[4-(benzyloxy)phenyl]acetaldehyde (40167-10-0)

Guidance literature:

Kinetics; UV-irradiation;

DOI:10.1039/c3sc50500f

upstream raw materials:

2-(4-benzyloxyphenyl)ethanol

p-hydroxyphenethyl alcohol

benzyl chloride

p-benzyloxystyrene

Downstream raw materials:

4,4-ethylenedioxy-1-(4'-phenylmethoxyphenyl)cyclohexene

(E)-4-(4-benzyloxyphenyl)-2-butenoic acid ethyl ester

(2S,3S)-4-(4'-benzyloxyphenyl)-1,2-epoxy-3-hydroxybutane

(2S,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxybutan-1-ol

Refernces

• 1、 -. "Butenolide derivative as well as preparation method and application thereof". Paragraph 0052-0054; 0058. . Retrieved 2020/07/21.
• 2、 Moreno-Cinos, Carlos,Sassetti, Elisa,Salado, Irene G.,Witt, Gesa,Benramdane, Siham,Reinhardt, Laura,Cruz, Cristina D.,Joossens, Jurgen,Van Der Veken, Pieter,Br?tz-Oesterhelt, Heike,Tammela, P?ivi,Winterhalter, Mathias,Gribbon, Philip,Windshügel, Bj?rn,Augustyns, Koen. "α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease". . p. 774 - 797. Retrieved 2019/01/30.