2,2,6,6-Tetramethyl-4-piperidone oxime

Base Information

• Chemical Name: 2,2,6,6-Tetramethyl-4-piperidone oxime
• CAS No.: 4168-79-0
• Molecular Formula: C9H18 N2 O
• Molecular Weight: 170.255
• European Community (EC) Number: 224-026-9
• DSSTox Substance ID: DTXSID8063331
• Nikkaji Number: J17.314B
• ChEMBL ID: CHEMBL1401246
• Mol file: 4168-79-0.mol

Synonyms:4168-79-0;2,2,6,6-Tetramethyl-4-piperidone oxime;Triacetonamine oxime;2,2,6,6-tetramethylpiperidin-4-one oxime;4-Piperidinone, 2,2,6,6-tetramethyl-, oxime;N-(2,2,6,6-tetramethylpiperidin-4-ylidene)hydroxylamine;EX 4826;EINECS 224-026-9;BRN 0122417;2,2,6,6-Tetramethyl-4-piperidinone oxime;4-Piperidone, 2,2,6,6-tetramethyl-, oxime;1-21-00-00273 (Beilstein Handbook Reference);N-hydroxy-2,2,6,6-tetramethylpiperidin-4-imine;Oprea1_419204;MLS000038117;SCHEMBL4877698;CHEMBL1401246;DTXSID8063331;FFUVOHCLAIYVTL-UHFFFAOYSA-;HMS1615G14;HMS2340F19;MFCD00234585;STL293358;AKOS001674463;2,2,6,6-tetramethyl-4-oximinopiperidine;2,2,6,6-tetramethylpiperidin-4-oneoxime;SMR000034718;2,2,6,6-Tetramethyl-4-oxyiminopiperidine;LS-117340;2,2,6,6-tetramethyl-piperidin-4-one oxime;CS-0452396;T1743;2,2,6,6-Tetramethyl-4-piperidinone oxime #;D92517;AC-907/25004971

Chemical Property of 2,2,6,6-Tetramethyl-4-piperidone oxime

Chemical Property:

• Melting Point: 153°C
• Refractive Index: 1.4790 (estimate)
• Boiling Point: 253.1°Cat760mmHg
• Flash Point: 106.9°C
• PSA: 44.62000
• Density: 1.04g/cm³
• LogP: 2.08600
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 170.141913202
• Heavy Atom Count: 12
• Complexity: 189

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,2,6,6-Tetramethyl-4-piperidone Oxime ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC(=NO)CC(N1)(C)C)C

Technology Process of 2,2,6,6-Tetramethyl-4-piperidone oxime

There total 6 articles about 2,2,6,6-Tetramethyl-4-piperidone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2,6,6-Tetramethyl-4-piperidone (826-36-8) → 4-hydroxyimino-2,2,6,6-tetramethylpiperidine (4168-79-0)

Guidance literature:

With hydroxylamine; In sulfuric acid; for 1h;

Reference yield: 95.0%

tris-2-oxypropylamine (63206-89-3) → 4-hydroxyimino-2,2,6,6-tetramethylpiperidine (4168-79-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In water; at 60 ℃; for 0.5h;

DOI:10.1021/jm101232t

Reference yield:

acetone (67-64-1) → 2,2,6,6-Tetramethyl-4-piperidone (826-36-8) + 4-hydroxyimino-2,2,6,6-tetramethylpiperidine (4168-79-0) + 2,3-dimethyl-2,3-dinitrobutane (3964-18-9) + acetone oxime (127-06-0)

Guidance literature:

With ammonia; dihydrogen peroxide; In water; at 59.84 ℃; for 1.5h; Solvent; Reagent/catalyst;

DOI:10.1016/j.apcata.2014.09.038

upstream raw materials:

2,2,6,6-Tetramethyl-4-piperidone

tris-2-oxypropylamine

acetone

Downstream raw materials:

1-cyclohexyl-3-(2'.2'.6'.6'-tetramethyl-piperidin-4'-yl)-urea

2,2,6,6-tetramethyl-4-(3-methyl-3-nitrosoureido)piperidine-1-oxyl

1-cyclohexyl-3-(2'.2'.6'.6'-tetramethyl-piperidin-4'-yl-1'-oxyl)-urea

tempamine

Refernces

• 1、 Wang, Yi,Zhang, Shengjian,Zhao, Yingxian,Lin, Min. "The mechanism of catalyst deactivation and by-product formation in acetone ammoximation catalyzed by hollow titanium silicalite". . p. 1 - 6. Retrieved 2014/02/14.
• 2、 Zakrzewski, Jerzy,Krawczyk, Maria. "Reactions of nitroxides. Part X: Antifungal activity of selected sulfur and selenium derivatives of 2,2,6,6-tetramethylpiperidine". scheme or table. p. 514 - 516. Retrieved 2011/02/28.